High PSALow volume diseaseRarely, patients with prostate cancer (PC) present with Prostate-Specific Antigen (PSA) scores >20ng/mL but otherwise very low-risk disease. Oncologists debate whether malignancies in these patients behave more comparably to low-risk or high-risk disease. Our objective ...
Prostate cancer is a common type of cancer that affects men, and it occurs in the prostate gland which is a part of the male reproductive system. High-risk prostate cancer refers to aggressive and advanced forms of the disease that are more likely to spread to other parts of the body. T...
Prostate-specific antigen (PSA) is the tumor marker most widely used in conjunction with digital rectal examination (DRE) for the early detection of prostate cancer (PCa). Due to its limitations, especially the high rate of false positive (FP) results, PSA screening of transplant candidates is...
High-Risk Prostate Cancer Treated With Dose-Escalated RT: An Analysis of Hormonal Therapy Use and Duration, and Prognostic Implications of PSA Nadir ≤0.2 ... OBJECTIVES:: To determine prognostic factors to select high-risk men receiving dose-escalated radiation therapy (RT) who will have favorabl...
The median age was 68 years, the median PSA level was 34 ng/mL, 39% of the population was node-positive, and 3% had relapsed after prior treatment. Total median follow-up was 72 months, but follow-up was longer for the AAP versus APP plus e...
Log-rank tests were used to determine significance with the clinical endpoint being biochemical recurrence (BCR), defined as PSA ≥ 0.2 ng/mL following RP. P-values below 0.05 were considered significant. PSMA expression and CD8+ T-cell infiltration in prostate tissue samples were ...
Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral ... Purpose;Prostate cancer (PCa) prevention remains an appealing strategy for the reduction of overtreatment and secondary adverse effects. We evalu...
Introduction High-risk prostate cancer is defined by the National Comprehensive Cancer Network (NCCN) as disease with a serum prostate-specific antigen (PSA) level greater than 20 nanograms per milliliter (ng/mL; to convert to μg/L, multiply by 1), a clinical T category 3 or 4, or a...
Performance Measure Calculations for High-Grade Cancer using PSA Alone, Prostate Cancer Prevention Trial Risk Calculator, Prostate Health Index (PHI), Derived Multiplex 2-Gene and 3-Gene Models, MyProstateScore (MPS), MPS2, and MPS2 Plus Prostate Volume (MPS2+) in the EDRN Validation Cohort ...
b. Distributions of age (n = 125) and plasma PSA (n = 117) levels of patients in our cohort. For the boxplot, center line indicates the median value, lower and upper hinges represent the 25th and 75th percentiles, respectively and whiskers denote 1.5 × interquartile range. c....