Outlines the results of a study on the treatment of prostate cancer. Significance of the prostate specific antigen; Ability of the antigen to reduce metastases; Experiment on in vitro cells.JosefsonDebbieBMJ: British Medical Journal (International Edition)...
Results of rebiopsy for suspected prostate cancer in sympto- matic men with elevated PSA levels. Eur Urol 1997; 32:155–159. 55 Gaudin PB, Sesterhenn IA, Wojno KJ, et al. Incidence and clinical significance of high-grade prostatic intraepithelial neoplasia in TURP specimens. Uro- logy 1997;...
referred to as “cases”: men with a diagnostic code of CaP who had no record of cancers other than CaP and nonmelanoma skin cancer and men with at least two elevated PSA results, defined as PSA > 2.5 ng/mL, but no diagnosis of CaP. Given that there is a continuum of CaP risk a...
While a correlation trend was detected for the pathological tumor (pT) stage (p = 0.09, likelihood-ratio test), we found no significant association with histological tumor (Gleason) grade or total serum PSA, contrary to previous findings23. When looking only at non-synonymous mtDNA mutations...
1 for correlation between tasks & Supplementary Figs. 2, 5, 8, 11, 14 for descriptive analysis of the outcomes). Note that BCR is defined as a rising PSA of >0.2 ng/ml or the initiation of a secondary treatment in response to elevated PSA levels following RP....
Nonmetastatic CRPC is often detected biochemically, through a rise in prostate-specific antigen (PSA) levels in men who are currently taking ADT. It remains unknown how to optimally treat this population since the standards of care for metastatic disease do not apply to these individuals. Preventi...
DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8(+) T-cell responses and increases PSA doubling time. Cancer Immunol Immunother. 2012; 61:2161-2170.Chudley, L.; McCann, K.; Mander, A.; Tjelle, T.; Campos-Perez, J.; Godeseth, R.; Creak, A.; ...
Mutations detected only in a single sample (private mutations) appear in gray in the rightmost columns. The number of SNVs in each cluster is shown at the bottom of the columns. b Cladogram of the evolutionary clusters in GP5 cancer. The MRCA, represented by Cluster T, branched into two...
featuredeep radiomics 3emerges as the most discriminating feature. Once again, four of six DLRs are in the top nine most important features. For other tasks, the model’s predictions are mainly explained by secondary Gleason score, except for CRPC-FS, where prostate-specific antigen (PSA) ...
Diagnostic and therapeutic decisions are commonly driven by anomalous levels of PSA in patients’ blood while, on the other hand, this antigen is known to be prostate-specific but not cancer-specific8. The standard screening threshold of 4.1 ng/mL has recently been challenged and accurate cut...