High PSA levels may show body is fighting cancer.Outlines the results of a study on the treatment of prostate cancer. Significance of the prostate specific antigen; Ability of the antigen to reduce metastases; Experiment on in vitro cells.Josefson...
Can urinary PCA3 supplement PSA in the early detection of prostate cancer? J Clin Oncol. 2014;32(36):4066-4072.PubMedGoogle ScholarCrossref 41. Gittelman MC, Hertzman B, Bailen J, et al. PCA3 molecular urine test as a predictor of repeat prostate biopsy outcome in men with previous ...
Can urinary PCA3 supplement PSA in the early detection of prostate cancer? J Clin Oncol. 2014;32(36):4066-4072. doi:10.1200/JCO.2013.52.8505PubMedGoogle ScholarCrossref 21. Thompson IM, Ankerst DP, Chi C, et al. Assessing prostate cancer risk: results from the Prostate ...
Similar to GP5, selecting the two largest tumor foci (1-RMidApicalCA/2-LMidApicalCA) as the “index” lesion identifies only 16/36 (44.4%) driver changes identified in GP12 metastatic subclones (Additional file 1: Supplementary Results). Tracing the anatomic origins of cancer metastases using ...
Can the number of cores with high-grade prostate intraepithelial neoplasia predict cancer in men who undergo repeat biopsy? To evaluate whether the presence of, or the number of cores containing, high-grade prostatic intraepithelial neoplasia (PIN) found in men who underwent ini... Y Naya,AG Ay...
Pathology results were reviewed to determine detailed core involvement as well as Gleason score (GS). High-volume biopsy core involvement was defined as ≥ 50%. Weighted Gleason core involvement was reviewed, giving higher weight to higher-grade cancer. The PSA kinetics and oncologic outcomes ...
Portland, OR-Weekly preoperative chemotherapy with docetaxel (Taxotere)and mitoxantrone (Novantrone) reduced PSA levels and was associated witha high rate of negative surgical margins in a small preliminary clinicaltrial involving high-risk localized prostate cancer patients....
Cancer immunotherapies such as bispecific T-cell engagers have seen limited adoption in prostate cancer (PC), possibly due to differing levels of cancer receptor expression and effector T-cell infiltration between patients and inherent defects in T-cell engager design. Methods CD8+ T-cell infiltration...
1 In 2012, the US Preventive Services Task Force recommended against routine prostate-specific antigen (PSA) screening owing to risk of overdiagnosis of clinically insignificant prostate cancer. Consequently, there has been a decrease in indolent, localized disease, but a concordant increase of ...
Following treatment completion, patients were followed with mostly lab assessment until PSA progression, at which point, treatment was per investigator discretion.” Breast Cancer Overall survival (OS) results from the phase III TROPiCS-02 study of sacituzumab govitecan (SG) vs treatment of ...