Temple, Texas, USAObjective: To describe leptomeningeal myelomatosis (LM) in previously treated high-risk kappa light chain multiple myeloma (MM) and to review the literature.Case report: A 71-year-old female with previously treated kappa light chain myeloma presented with right lumbosacral discomfo...
A series of detection scAbs recognising various tau epitopes were added at 10 µg/mL and detected using HRP-conjugated anti-human kappa light chain antibody as described above. LLOQ was calculated as the lowest dilution in the standard curve with signal higher than the average blank value plus...
(w/v) dried milk powder in PBS, prior to adding scAbs or mAbs in doubling dilution. The binding was detected using HRP-conjugated anti-human kappa light chain antibody (for scAbs; Sigma, #A7164) and HRP-conjugated anti-mouse IgG (for mAbs; Sigma, #A6782) as the secondary antibody and...
Elevated Serum Free Light Chains Are Associated With Event-Free and Overall Survival in Two Independent Cohorts of Patients With Diffuse Large B-Cell Lymphoma The serum free light chain (FLC) assay quantitates free kappa (κ) and free lambda (λ) immunoglobulin light chains. This assay has prog...
Adoptive T cell therapy is a pivotal strategy in cancer immunotherapy, demonstrating potent clinical efficacy. However, its limited durability often results in primary resistance. High-throughput screening technologies, which include both genetic and non
Hence, the anti-inflflammatory activity of lupeol could be explained by the suppression of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) expression in keratinocytes and the regulation of MMP-2 (matrix metalloproteinase-2) [4...
(MDA) levels. Quantitative real-time polymerase chain reaction (PCR) was used to measure the expression of the receptor for advanced glycation end-products (RAGE) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Hematoxylin and eosin (H&E) staining was used to ...
Many patients struggle with long-term responses to adoptive T cell immunotherapy, often facing drug resistance or relapse post-treatment. Identifying factors influencing T cell functional persistence is critical. T cell exhaustion, characterized by diminished effector capacity and heightened immune response ...
both the serum protein electrophoresis (SPE) and immunofixation (IFE) assays used for the clinical monitoring of endogenous M-protein. This interference can impact the determination of complete response and of disease progression in some DARZALEXFASPRO®-treated patients with IgG kappa myel...
with IG–MYC rearrangement, 27 (79%) had rearrangement with the immunoglobulin (IG) heavy chain gene (IgH) [t(8;14)(q24.1;q32)], three (9%) with the IG kappa light chain gene [t(2;8)(p12;q24.1)] and four (12%) with the IG lambda light chain gene [t(8;22)(q24;q11.2)...