In contrast, cytosolic release of the mitochondrial protein cytochrome c may play a regulatory role by competing with NLRP3 for binding to cardiolipin [46]. A reduction in cardiolipin synthesis was shown to reduce NLRP3 inflammasome activation [41]. Comparatively, the requirement for both MAVS and...
8 In patients presenting with renal failure, hypercalcemia, or elevated LDH, treatment with a bortezomib-based regimen should be started as soon as possible to rapidly reduce the high tumor load to reverse and/or prevent complications. Although participation in clinical trials is strongly recommended...
The Delta variant has accumulated many non-synonymous mutations in the NDT supersite, changing its structure to reduce the neutralizing effect of anti-NDT antibodies. A meticulous analysis of the Delta variant's mutations in the NDT region shows that T19R is in the N1 region, V70F is in the...
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The kappa value was 0.92, which showed a high degree of inter-rater reliability [84]. 3.5. Measurements of Control Variables We also controlled for the following variables: (1) firm age, using the logarithm of distributor firm age; (2) firm size, using the logarithm of the distributor ...
Antimicrobial resistance: Risk associated with antibiotic overuse and initiatives to reduce the problem. Ther. Adv. Drug Saf. 2014, 5, 229–241. [Google Scholar] [CrossRef] [PubMed] Prestinaci, F.; Pezzotti, P.; Pantosti, A. Antimicrobial resistance: A global multifaceted phenomenon. Pathog...
Pressure from supermarkets to cut in-store costs of unpacking and shelf filling, maximise product display and reduce waste disposal combined with suppliers' need to control their costs of packaging materials has driven the rapid growth of shelf ready packaging. But retail demand has gone in differen...
Investigators have tried to identify how BoNT can reduce or stop itch. To understand the mechanisms underlying the antipruritic effects of BoNT, cell-based studies, laboratory animal investigations and human experimental models have been employed to provide the mechanism-based evidence that is presented...
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However, there is some ambiguity in choosing the number of points required to obtain the second line, which can reduce the reliability of the method. Figure 10. Methods for yield stress detection using amplitude sweeps: (a) intersection of the tangents of the storage modulus (G′); (b) ...