Borderline high serum free light chain k/ ratios are seen not only in dialysis patients but also in non-dialysis-dependent renal impairment and inflammatory states. Am J Clin Pathol 2009; 132: 309.Marshall G, Tate J, Mollee P. Borderline high serum free light chain kappa/lambda ratios are...
A series of detection scAbs recognising various tau epitopes were added at 10 µg/mL and detected using HRP-conjugated anti-human kappa light chain antibody as described above. LLOQ was calculated as the lowest dilution in the standard curve with signal higher than the average blank value plus...
(w/v) dried milk powder in PBS, prior to adding scAbs or mAbs in doubling dilution. The binding was detected using HRP-conjugated anti-human kappa light chain antibody (for scAbs; Sigma, #A7164) and HRP-conjugated anti-mouse IgG (for mAbs; Sigma, #A6782) as the secondary antibody and...
tssViuunLlbgtgsi1nee4qngueppseaa,nii4rrtsl8eydwrseeVesrquHeul/ctVeelnodLcngieeneddnrveieniscatofooSvarhenrerygeapveorylficsaVeanqtHdeugsleieengnqhceuitnsecgnoh.cnaOeliysnf,, mammalian expression plasmids containing human IgG1 constant regions and kappa light chain regions for chimeric ...
For example, conversion of Phe90 in the murine kappa light chain variable domain germline sequence IgkV9-124*01 to TyrL91 in 10G4 provided a hydrogen bond donor that stabilized a water-mediated contact to the C5-OH of the LTC4 arachidonic acid moiety, while mutation in the IgHV3-1*02 ...
(M-protein) level in the blood, but they do not yet exhibit the symptoms commonly associated with active multiple myeloma, particularly end-organ damage. Fifteen percent of all cases of newly diagnosed multiple myeloma are classified as smoldering multiple myeloma, and half of those dia...
Daratumumab is a human immunoglobulin G (IgG) kappa monoclonal antibody that can be detected on both the serum protein electrophoresis (SPE) and immunofixation (IFE) assays used for the clinical monitoring of en...
While its mother brand Robe di Kappa was founded in 1916, Kappa, as we know it today, began life in 1967. When we say "Kappa as we know it", we mean Kappa in its legend of sportswear propensity. With one of the most memorable logos ever — need "Omini" — Kappa made a splash ...
, 5., 6. Kappa light chains (LCs) are involved in about two-thirds of LCDD cases, with an overrepresentation of the VκIV subgroup.7 The usual presentation is with progressive kidney failure and glomerular symptoms, including nephrotic syndrome in half of patients. Uncommonly, MIDD may ...
Kappa-RBD produced by glycoengineered Pichia pastoris elicited high neutralizing antibody titers against pseudoviruses of SARS-CoV-2 variants [624]. U50,488 H, induced autophagy in Neuro-2A cells stably expressing the human KOR by upregulating microtubule-associated protein Light Chain 3-II (LC3-II...