Title: Appropriateness of Statin Dose in High Risk Patients Post-PCI/CABG at Gwinnett Medical CenterPrimary investigator: Brandon Cunningham, PharmDMentor: Mary George, PharmDBackground: American College of Cardiology (ACC)/American Heart Association (AHA) guidelines for cholesterol and acute coronary ...
This retrospective cohort study estimates the proportion of patients filling high-intensity statin prescriptions following myocardial infarction who
Among statin users, most were commenced on treat- ment within 90 days after stroke (84.3%) with a medium- intensity dose (73.8%). Those who did not change initial intensity through 2 years accounted for 86.4%. These statin use patterns were similar between patients with specified ischemic ...
The magnitude of these changes in the lipid profile will depend on the type of statin and the dose used; those that are able to decrease 50% or more low-density lipoproteins levels are called "high-intensity statins". In recent decades, the evidence from large randomized clinical trials with...
Changes in Statin Intensity in the Treat-to-Target Strategy Group eTable 3. Statin Intensity Between Groups eTable 4. Lipid-Lowering Therapy eTable 5. Cardiovascular Medications eTable 6. Serial Changes in Lipid Profiles eTable 7. Patients With LDL-C Below 70 mg/dL eTable 8. Patients ...
Finally, they studied the effect of different doses within the high-intensity statin group. Patients treated with the maximum dose of statins were 10 percent more likely to survive than patients on submaximal doses. "This suggests to practitioners that instead of starting a patient on a low dos...
We recently demonstrated, in a multi-center clinical trial, that statin therapy is associated with dose-dependent reduction in atheroslerotic inflammation (assessed with FDG-PET-CT). Here we conduct a post-hoc, blinded analysis of the images derived from that trial to test the hypothesis that ...
High-intensity statin is recommended for patients undergoing percutaneous coronary intervention (PCI), and ezetimibe is recommended to be added in patients not achieving low-density lipoprotein cholesterol (LDL-C) targets. Moderate-intensity statin plus ezetimibe can reduce LDL-C levels similar to high...
Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) to examine the effects of high-intensity statin therapy on IVUS-derived measures of coronary disease progression. Rosuvastatin is the most recently ...
LAPLACE-2 is to our knowledge the first study to demonstrate that the addition of evolocumab results in similar percent reductions in LDL-C and achieved LDL-C levels regardless of stable baseline statin type, dose, or intensity, across 3 commonly prescribed statins and a broad range of doses....