High-intensity statins benefit high-risk patients: why and how to do better. Mayo Clin Proc. 2021;96:2660–70. Article PubMed Google Scholar Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, et al. 2013 Acc/Aha Guideline on the treatment of blood ...
Although statins rank among the most extensively studied therapies in contemporary medicine, the optimal target levels for low-density lipoprotein cholesterol (LDL-C) remain controversial. Recently, several active control trials have reported that more intensive statin therapy results in a greater ...
American College of Cardiology (ACC)/American Heart Association (AHA) guidelines for cholesterol and acute coronary syndrome (ACS) recommend high intensity statins for secondary prevention in high-risk coronary artery disease patients as they have been proven to significantly reduce recurrence of cardiovas...
In patients with or at risk for atherosclerotic vascular disease, statins reduce the incidence of major adverse cardiovascular events, but the majority of US adults with an indication for statin therapy are not prescribed statins at guideline-recommended intensity. Clinicians' limited time to address ...
(within the previous 2 years) at a dose equivalent to atorvastatin ≥ 40 mg; history of liver disease, rhabdomyolysis, or allergy to statins; pregnancy or nursing; current use of medications known to interact with statins (e.g., cyclosporine, systemic itraconazole, clarithromycin, HIV protease ...
The total intensity of apoL1 showed a significant decrease in the HDL3 subfraction in exitus patients when compared with no exitus patients (P = 0.003; Fig. 8B). Similarly, total LCAT intensity was significantly decreased in HDL3 of exitus patients (P = 0.009; Fig. 8C). There were no ...
Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, etal: Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006, 295 (13): 1556-1565. 10.1001/jama.295.13....
cardiovascular magnetic resonance (CMR) and near-infrared spectroscopy (NIRS)-intravascular ultrasound (IVUS) (NIRS-IVUS), and to determine whether pre–percutaneous coronary intervention (PCI) evaluation using CMR identifies high-intensity plaques (HIPs) at risk of peri-procedural myocardial infarction ...
The lesions were categorized into a high-intensity statin group (n = 394 lesions) and a low-to-moderate intensity statin group (n = 150 lesions). Additionally, there were 39 lesions associated with patients not receiving statins (Figure 1). The ROCK registry did not include the use of ...
High-Intensity Statins Benefit High-Risk Patients: Why and How to Do Better. Mayo Clin. Proc. 2021, 96, 2660–2670. [Google Scholar] [CrossRef] [PubMed] Naeem, F.; McKay, G.; Fisher, M. Cardiovascular outcomes trials with statins in diabetes. Br. J. Diabetes 2018, 18, 7–13. [...