childrenhigh grade gliomainfantyoungHigh grade gliomas (HGG) have a dismal prognosis with survival rates of 15-35%. Approximately 10-12% of pediatric HGG occur in young children and their molecular biology and clinical outcomes differ from those arising at older ages. We report on four children...
To determine whether temozolomide is an active agent in the treatment of children with high-grade astrocytomas and whether survival is influenced by the expression of the O6-methylguanine-methyltransferase gene (MGMT) in these patients. In the Children's Oncology Group study ACNS0126, 107 patients...
High grade gliomaanaplastic astrocytomachildren gliomaglioblastoma multiformeBrain tumors are a major cause of cancer-related mortality in children. Overexpression of epidermal growth factor receptor (EGFR) is detected in pediatric brain tumors and receptor density appears to increase with tumor grading. ...
Unlike high-grade glioma in adults, these tumors represent a minority of all primary central nervous system neoplasms in the pediatric age group ( 3 years, the role of chemotherapy is less clear. Despite the use of multimodality therapy, less than 20 percent of these children are long-term su...
Although the prognosis for survival of supratentorial high-grade glioma is not as ominous in children as in adults, this survival advantage may be in part a result of stronger constitution of children as well as differences in the molecular genetic substrate of the neoplasm....
High-grade glioma (HGG) of the cerebellum accounts for only 5% of paediatric HGG. Since little is known about these tumours, the present study aimed at their further characterisation. Methods: Twenty-nine paediatric patients with centrally reviewed cerebellar HGG were identified from the HIT-GBM/HI...
Chemotherapy is commonly used in the treatment of children with high-grade glioma, although its usefulness is uncertain. We conducted a multi-institutional study to evaluate the efficacy of temozolomide given after radiotherapy in children with newly diagnosed high-grade glioma and unfavorable low-grade...
The EU Research Strategy for High Grade Glioma in Children and Adolescents - Can We Extrapolate From Adult Data?doi:10.1016/S0959-8049(11)70415-4D. HarqraveElsevier LtdEuropean Journal of Cancer
High-grade gliomas (HGGs) constitute approximately 10 % of all childhood brain tumors and include AA (anaplastic astrocytoma), anaplastic oligodendroglioma (AO), and glioblastoma (GBM). Clinical symptomatology varies greatly with age and can be nonspecific, especially in younger children. Conventional ...
Brain tumours are the leading cause of cancer-related death in children, and there is no effective treatment. A growing body of evidence points to deregulated epigenetics as a tumour driver, particularly in paediatric cancers as they have relatively few