Our understanding of the genetic and molecular changes that drive these tumors has grown exponentially due to data gathered by the Cancer Genome Atlas and other groups, and this data is already being translated into new therapeutic strategies. As we move further into the era of personalized ...
Mutations of theisocitrate dehydrogenase gene(IDH) were recognised in 2008 as an early event in glioma genesis [8]. Mutations in theIDHgene 1 or 2 are hallmarks of low-grade glioma; when observed in high-grade glioma, it suggests that the tumour has developed from a lower grade precursor ...
High-grade gliomas (HGG) are a devastating group of cancers, and represent the leading cause of brain tumour-related death in both children and adults. Therapies aimed at mechanisms intrinsic to glioma cells have translated to only limited success; effective therapeutic strategies will need also to...
Chimeric antigen receptor T cell (CAR-T) therapy is an emerging strategy to improve treatment outcomes for recurrent high-grade glioma, a cancer that responds poorly to current therapies. Here we report a completed phase I trial evaluating IL-13Rα2-targ
High Grade Glioma: Glioblastoma (GBM)Also known as: Glioblastoma / Glioblastomas / Glioblastoma (GBM) / Glioblastomas (GBM) / GBM / Glioblastoma (morphologic abnormality) / Glioblastoma multiforme / Glioblastoma multiforme (disorder) Drugs Drugs and Targets Drug Trials DrugDrug NameDrug Description ...
Cerebellar location may predict an unfavourable prognosis in paediatric high-grade glioma. Br J Cancer. 2013;109(4):844–51. Article PubMed PubMed Central CAS Google Scholar Jeswani S, Nuno M, Folkerts V, Mukherjee D, Black KL, Patil CG. Comparison of survival between cerebellar and ...
Molecular subtype impacts surgical resection in low-grade gliomas: A Chinese Glioma Genome Atlas database analysis Surgeons have considered extending the resection margins for better outcomes in gliomas, but have not considered molecular pathology. We investigated the i... ZH A,KNZ A,LB Xing,......
Summary Patients with high-grade glioma (HGG) can be classified as having a favourable prognosis (younger or with good performance status) or a poor prognosis (older or with poor performance status) with median survival of 12–24 months and 6–9 months, respectively. The standard management for...
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Activated oncogenic signaling is central to the development of nearly all forms of cancer, including the most common class of primary brain tumor, glioma. ... Huse,T Jason,Brennan,.....
Pediatric high-grade glioma (pHGG) is a major contributor to cancer-related death in children. In vitro and in vivo disease models reflecting the intimate connection between developmental context and pathogenesis of pHGG are essential to advance understa