The molecular diagnostic test of key tumor gene mutations as well as drug-targeted mutations in patients who failed tissue test has been widely adopted [21,22,23]. One of the earliest applications of ctDNA detection is to identify epidermal growth factor receptor (EGFR) mutations for the ...
Adoptive T cell therapy is a pivotal strategy in cancer immunotherapy, demonstrating potent clinical efficacy. However, its limited durability often results in primary resistance. High-throughput screening technologies, which include both genetic and non
Chronic kidney disease was defined as a deterioration of at least 30% in the estimated glomerular filtration rate (eGFR)—-the rate at which kidneys remove waste and extra water from blood to make urine—to less than 60 ml/min. The average total weekly tally of moderate to vigorous physical...
Vascular smooth muscle cells (VSMCs) frequently account for related pathophysiological processes within the blood vessel wall. Unlike many other mature cell types in the adult body, VSMCs do not terminally differentiate but retain a remarkable plasticity3. Predominantly, they are found in two ...
The eGFR (milliliter per minute per 1.73 m2) was computed using the Chronic Kidney Disease Epidemiology Collaboration equation.16 Medications were obtained by self-report and medical records review.Fasting total cholesterol, HDL-C, and triglyceride levels were assayed (Beckman Coulter). LDL-C level...
EGFR epidermal growth factor receptor EGR1 early growth response 1 EGR2 early growth response 2 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 ELK1 ELK1, ETS transcription factor ELOB elongin B ENG Endoglin ENO1 enolase...
from each group (in total 16 goats) were selected for slaughter and sampling at the end of the trial (on day 90). Sample collection Before the slaughter on day 90, blood samples were collected from jugular vein into 5-mL endotoxin free vacuum blood collection tubes and were then put into...
And they had relatively higher WC, body weight, BP, FPG, non-HDL-C, serum uric acid, THR and lower eGFR levels (Table 1). Table 1 Baseline characteristics of very elderly according to MetS (Chinese criteria). Full size table Participants with lower tertile category of THR had a lower ...
Cancer immunotherapies such as bispecific T-cell engagers have seen limited adoption in prostate cancer (PC), possibly due to differing levels of cancer receptor expression and effector T-cell infiltration between patients and inherent defects in T-cell engager design. Methods CD8+ T-cell infiltration...
1 Although 8.6% of individuals with an estimated glomerular filtration rate (eGFR) >60 ml/min per 1.73 m2 had albuminuria, it was identified in approximately 75% of individuals with advanced CKD (eGFR <30 ml/min per 1.73 m2).1 However, the awareness of kidney disease among individuals with...