Mechanistically, miR-30b-5p suppresses the progression and metastasis of PTC by targeting GALNT7 and subsequently inhibiting the EGFR/PI3K/AKT pathway [128] (Fig. 4). PI3K/AKT is also an important metastasis-related signalling pathway in ATC and PDTC, and PIK3CA mutation contributes to the ...
However, the administration of gadolinium during MRI has been strongly linked to nephrogenic systemic fibrosis, a fibrosing disorder of the skin that develops in patients with reduced eGFR, particularly those receiving dialysis. As a result, gadolinium-based imaging must be avoided in patients with ...
BMI for both cohorts was calculated as weight in kilograms divided by height in meters squared. Serum creatinine at enrollment before cardiac catheterization was obtained from routine clinic visits or hospitalizations within the Emory Healthcare system. The eGFR (milliliter per minute per 1.73 m2) ...
The estimated glomerular filtration rate (eGFR) was calculated by using the Modification of Diet in Renal Disease study equation modified for the Chinese: eGFR = 186 × serum creatinine−1.154 × Age−0.203 × 0.742 (if women). Diagnostic criteria of MetS In this study...
The molecular diagnostic test of key tumor gene mutations as well as drug-targeted mutations in patients who failed tissue test has been widely adopted [21,22,23]. One of the earliest applications of ctDNA detection is to identify epidermal growth factor receptor (EGFR) mutations for the ...
To invade these cells, gonococci interact with heparin sulphate proteoglycan (HSPG) receptor leading to activation of epidermal growth factor receptor (EGFR). The activation of EGFR-associated signaling pathways leads to a decreased expression of integrin, increased β-catenin phosphorylation, and E-...
Adoptive T cell therapy is a pivotal strategy in cancer immunotherapy, demonstrating potent clinical efficacy. However, its limited durability often results in primary resistance. High-throughput screening technologies, which include both genetic and non
[116]. Other studies have reported similar synergistic effects for high-dose VitC combined with EGFR inhibitors cetuximab and gefitinib in KRAS mutated colon cancer and NSCLC cells respectively [99,109]. Interestingly, Jung et al. [99] showed that medium-dose VitC (0.5 g kg− 1) ...
EGFR epidermal growth factor receptor EGR1 early growth response 1 EGR2 early growth response 2 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 ELK1 ELK1, ETS transcription factor ELOB elongin B ENG Endoglin ENO1 enolase...
Male sex, increasing age and systolic blood pressure were independent determinants of both hsTnT and hsTnI. Despite normal renal function (eGFR≥60 mL/min/1.73 m2) in all individuals, a lower eGFR was independently associated with higher hsTnT concentrations, but not with hsTnI (Table 3)...