The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and ...
Hemoglobin affinity for oxygen in three subspecies of toads (Bufo sp.) living at different altitudes. Blood oxygen affinity and red blood cell properties were measured in three subspecies of genus Bufo: Bufo spinulosus limensis, collected at sea level and a... H,Ostojic,C,... - 《Biological...
By introducing an additional H-bond in the α 1β 2 subunit interface or altering the charge properties of the amino acid residues in the α 1β 1 subunit interface of the hemoglobin molecule, we have designed and expressed recombinant hemoglobins (rHbs) with low oxygen affinity and high coo...
Inherited protein S deficiency and the presence of a rare high oxygen affinity hemoglobin variant: Hb Rainier [ 145 (HC2) Tyr Cys] were found in a family. Among 16 studied members, nine were found as carriers of protein S deficiency (type I with decrease of total, free, and activity leve...
Oxygen affinity 1. Introduction Hemoglobin-based oxygen carriers (HBOCs) have been investigated for more than 40 years as possible substitutes for whole blood transfusions. HBOCs are based on cell-free hemoglobin (Hb) that has undergone either chemical or genetic modifications to increase its retent...
As a consequence of this substitution, there is compensated hemolysis, instability, increased oxygen affinity, and reduced cooperativity. However, the health of the individual is hardly affected.关键词: Hemoglobin variant Hemoglobin instability Oxygen affinity High pressure liquid chromatography ...
This paper presents an innovative approach for predicting the relative populations of protein conformations using AlphaFold 2, an AI-powered method that has revolutionized biology by enabling the accurate prediction of protein structures. While AlphaFold
(e.g., <4 µM for all 2016 samples; Fig.1c) were below the optimum for comammoxNitrospira. Consistent with an “oligotrophic lifestyle”, Kits et al. [63] reported a high apparent affinity of “Ca. Nitrospira inopinata” for ammonium (Km(app)of 0.65–1.1 µM total ...
A Similar phenomenon has been demonstrated in the CrMnFeCoNi Cantor alloy in which the Mn element is replaced by the Pd element to induce the different element affinity and tune element distribution for achieving chemical inhomogeneity8. Therefore, the atomic-scale element distributions of Zr15Nb14H...
The activity of nanomaterials (NMs) in catalytically scavenging superoxide anions mimics that of superoxide dismutase (SOD). Although dozens of NMs have been demonstrated to possess such activity, the underlying principles are unclear, hindering the disc