To clarify the influence of blood flow with high-oxygen (O2)-affinity blood on oxygen consumption (VO2) in submaximally exercising skeletal muscle, we perfused the isolated dog gracilis (n = 8) contracting under 1 Hz stimulation alternatively with normal and high-O2-affinity blood, with a ...
diffusion bonding of austentitic steels and nimonic type of alloys without an interlayer, explains the mechanism of joint development by using an interlayer of material having a great affinity to oxygen, for example nickel or cobalt, and gives a new criterium for selecting metal for the ...
The latch structure is a hydrogen bond formed between the main chain oxygen of Val332 and the side chain amide nitrogen of Gln386. All red-like Rubiscos conserve Gln386 to form the latch structure. On the other hand, green-like Rubiscos cannot form the latch structure because Gln386 is ...
By introducing an additional H-bond in the α 1β 2 subunit interface or altering the charge properties of the amino acid residues in the α 1β 1 subunit interface of the hemoglobin molecule, we have designed and expressed recombinant hemoglobins (rHbs) with low oxygen affinity and high coo...
Fig. 3: Identification of high-affinity allosteric inhibitors for SERT. a Chemical structure of three tested compounds, all based on S-CIT template with an amide instead of the cyano in S-CIT. They differ in having either none (AE), one (Lu AF60097) or two (AF) double bonds (stippled...
The Ca2+ phospholipid-binding protein with a high affinity for phosphatidylserine was quantified by gating the false-color mapping fluorescence using Olympus CellSens Dimension software (v1.17) and statistically analyzed. GSIS assay GSIS assays were conducted to assess in vitro function of islets26. ...
Oxygen affinity 1. Introduction Hemoglobin-based oxygen carriers (HBOCs) have been investigated for more than 40 years as possible substitutes for whole blood transfusions. HBOCs are based on cell-free hemoglobin (Hb) that has undergone either chemical or genetic modifications to increase its retent...
In chick embryos, developmental changes of the blood oxygen tension control hemoglobin (Hb) oxygen affinity via modulation of ATP and 2, 3BPG concentrations in red blood cells. Hypoxia, which is a normal developmental condition for late chick embryos, causes a decrease of the red cell ATP conce...
Studies conducted over the last three decades provide indirect evidences that H2 soil uptake is mediated by free soil hydrogenases or by unknown microorganisms that have a high affinity for H2. The exact nature of these hypothetical free soil enzymes or of H2-consuming microorganisms remains elusive...
The compound N-(4-hydroxyphenyl)arachidonylamide (AM404) was shown to inhibit high-affinity anandamide accumulation in rat neurons and astrocytes in vitro, an indication that this accumulation resulted from carrier-mediated transport. Although AM404 did not activate cannabinoid receptors or inhibit ...