a qPCR analysis of the mRNA expression of HIF1A downstream DNA repair-target genes in C11orf54 knockdown and control cells (n = 4 biological replicates, data are presented as mean values ± SD, ***p < 0.001). b, c Western blots (b) and quantitative results (c) of the ...
PAFAH1B2 is a HIF1a target gene and promotes metastasis in pancreatic cancerCan Ma aYan Guo bYan Zhang aAixia Duo aYitao Jia aCi Liu aBinghui Li aBiochemical and Biophysical Research Communications
Th17 cells differ from the Th1 and Th2 lineages in secretion of interleukin (IL)-17 (refs 7,8), which induces inflammatory gene expression in target cells and leads to pathogenesis in the EAE model9. Transforming growth factor (TGF)-b is critical for the commitment to the Th17 lineage10,...
VMP1 is a novel target gene required for HIF1a-Induced autophagy in pancreatic cancer cell 来自 Semantic Scholar 喜欢 0 阅读量: 10 作者: Vaccaro, Maria Ines,Catrinacio, Cintia,Ropolo, Alejandro 摘要: Background. Pertuzumab and T-DM1 are two recently approved monoclonal antibody based therapies...
Overexpression of the HIFalpha subunits in different cell lines also led to a loss of target gene specificity. In conclusion, we found a remarkably restricted target gene specificity of the HIFalpha subunits, which can be overcome in cells with perturbations in the pVHL/HIF system and under ...
Role of Hif-1a and its target gene PTP4A3 in regulating cell proliferation during benzene exposureNo Abstractdoi:10.1016/j.toxlet.2018.06.862Pu, Y.Sun, R.Sun, F.Zhang, J.Yin, L.Man, Z.Pu, Y.TOXICOLOGY LETTERS
This report demonstrates that hypoxia-induced K63-polyubiquitinated HAUSP deubiquitinates HIF-1a and causes CBP-mediated H3K56 acetylation on HIF-1a target gene promoters to promote EMT/metastasis, further defining HAUSP as a therapeutic target in hypoxia-induced tumour progression. 1 Research Center...