These drugs might represent an important component of novel combination therapies that are designed to target signalling molecules in cancer cells. Abstract Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including ...
Therefore, HIF-1 is expected to be a potential pharmacological target for cancer therapy. Small molecules derived from natural products (microbial origin, plant-derived, or marine organisms) have been shown to have unique chemical structures and biological activities, including HIF-1 inhibition. ...
G.L. Semenza Targeting HIF-1 for cancer therapy Nat. Rev. Cancer, 3 (2003), pp. 721-732, 10.1038/nrc1187 View in ScopusGoogle Scholar 28 G.L. Semenza HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus Cell, 107 (2001), pp. 1-3 View PDFView art...
Semenza, G. L. Targeting HIF-1 for cancer therapy.Nature Rev. Cancer3, 721–732 (2003). ArticleCASGoogle Scholar Poon, E., Harris, A. L. & Ashcroft, M. Targeting the hypoxia-inducible factor (HIF) pathway in cancer.Expert Rev. Mol. Med.11, e26 (2009). ArticlePubMedGoogle Scholar...
Yang X,Yang B,Cai J,et al.Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1αin vitro and in vivo. Cancer Biology and Therapy . 2013Yang X,Yang B,Cai J.Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1αin vitro and in ...
Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011; 8:399-411. [PubMed: 21474104]Wang, Y.; Liu, Y.; Malek, S.N.; Zheng, P.; Liu, Y. Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 2011, 8,...
Targeting apoptosis pathways in cancer therapy. Killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, e.g. chemotherapy, γ-irradiation, immunotherapy or suicide ... S Fulda,KM Debatin - 《Current Cancer Drug Targets》 被引量: 1547发表: 2010年 γδ T ...
Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and metastasis t
current developments on TIGIT for cancer immunotherapy and discuss the characteristics and functions of TIGIT. Introduction Immune checkpoint inhibitors (ICIs) function by restoring the induction, activation, and expansion of tumor-specific cytotoxic T cells, resulting in durable therapy responses [1,2,3...
L. Targeting HIF-1 for cancer therapy. Nature Rev. Cancer 3, 721–732 (2003). Article CAS Google Scholar Poon, E., Harris, A. L. & Ashcroft, M. Targeting the hypoxia-inducible factor (HIF) pathway in cancer. Expert Rev. Mol. Med. 11, e26 (2009). Article PubMed Google Scholar...