仿生多细胞动态共培养系统 参考文献:Jia Y, Chen J, Zheng Z, Tao Y, Zhang S, Zou M, Yang Y, Xue M, Hu F, Li Y, Zhang Q, Xue Y, Zheng Z. Tubular epithelial cell-derived extracellular vesicles induce macropha...
经典活化巨噬细胞(classical activated macrophage, M1)是促炎细胞因子的主要产生者,被认为是哮喘和慢性气道炎症加重的罪魁祸首;FA可以通过诱导HIF-1α信号调节糖酵解来增强巨噬细胞的促炎反应。HIF-1α是一种转录因子,通常被认为在...
Hypoxia-inducible factor-1α(HIF-1α) is essential in the process of macrophage polarization, serving as a hub linking glucose metabolic activity to immunity. This review summarizes the research progress of HIF-1α-regulated macrophage polarization and its role in tumors, autoimmune diseases, atheros...
Authors - Bide Tong View Article IF Adv Sci (Weinh) Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis Authors - Bin Liu View Article See more citationsProteintech North America (HQ) Proteintech Group, Inc 5500 Pearl Street, Suite 400...
(生物谷Biooon.com) 参考文献 Nuria Pescador et al. Metformin reduces macrophage HIF1α-dependent proinflammatorysignaling to restore brown adipocyte function in vitro. Redox Biol 2021 Oct 19;48:102171. doi: 10.1016/j.redox.2021.102171.
Macrophages play very crucial and diverse roles in the pathogenesis of inflammatory vascular diseases. Macrophages are the principal innate immune cells recruited to arterial walls to govern vascular homeostasis by modulating the proliferation of vascular smooth muscle cells, reorganization of extracellular ma...
SinducedHIF-1aproteinaccumulationinTHP-1macrophagesinaconcentration- dependentmanner.WesternblotanalysisofcellfractionsshowedthatHIF-1aproteintranslocates intothenucleusandleadstoanincreaseofitstargetproteinglucosetransporter-1(GLUT-1).Activation ofnuclearfactor-kB(NF-kB),aswellassecretionofthepro-inflammatorycyt...
The role of glycolysis in macrophage migratory capacity 巨噬细胞的迁移和活化是促进炎症过程的两个关键功能。在炎症过程中,源自单核细胞的巨噬细胞从血管中渗出并在数小时内迁移到组织损伤或感染部位。虽然血管内的氧含量不低,在在炎...
Thus, Mint3 regulates the FIH-1-HIF-1 pathway, which controls ATP production in macrophages and therefore represents a potential new therapeutic target to regulate macrophage-mediated inflammation. 展开 关键词: Humans Macrophages Mixed Function Oxygenases Repressor Proteins Adenosine Triphosphate Protein ...
(by decreasing cellular ATP levels), neutrophil bactericidal potency, and macrophage migration (4). In this issue of the JCI, Peyssonnaux et al. (5) built on this foundation and attempted to understand the specific molecular defects contributing to depressed myeloid cell function in the absence...