We investigated the impact of HIF‐1α on MDSC accumulation and microbiome establishment during the neonatal period in a mouse model with targeted deletion of HIF‐1α in myeloid cells (Hif1a loxP/loxPLysMCre+). We show that in contrast to wildtype mice, where an extensive ...
这些结果通过免疫荧光染色得到证实(图4a,b,附加文件1:图。S3A-B)。然而,LINC00301似乎不影响髓源性抑制细胞(MDSCs;粒细胞和单核细胞)和肿瘤相关巨噬细胞(TAMs;图4a,b)。为了进一步证实这些结果,研究者使用从小鼠肿瘤中分离的单个细胞进行流式细胞术,并使用分离的肿瘤进行免疫荧光(IF)染色。结果表明,在C57BL/6...
(2014). PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. The Journal of Experimental Medicine, 211(5), 781–790. Article CAS PubMed PubMed Central Google Scholar Lee, J. H., et al. (2015). E3 ubiquitin ligase ...
to fulfill their function and could be corrupted to support tumor growth. Hypoxia enhances the immunosuppressive properties of Myeloid-Derived Suppressor Cells (MDSCs) toward T cells by a mechanism involved in the regulation of the immune checkpoint PD-L1 expression on the surface of MDSCs [14,15...
Myeloid-derived suppressor cells (MDSCs) possess immunosuppressive activities, which allow cancers to escape immune surveillance and become non-responsive to immune checkpoints blockade. Here we report hypoxia as a cause of MDSC accumulation. Using hepatocellular carcinoma (HCC) as a cancer model, we...
Granulocytic myeloid-derived suppressor cell (G-MDSC) expansion and IL-10 secretion are critical for inducing an immunosuppressive environment that supports S. aureus persistence during PJI. Recently, S. aureus-derived lactate was shown to promote IL-10 production by G-MDSCs. However, the ...
TNF-α signaling via NF-кB and IL6-JAK-STAT3 signaling, which were critical for the accumulation and immunosuppressive capacity of MDSCs [81,82,83,84,85,86,87]. Targeting MDSC trafficking has been reported to enhance anti-PD-1 efficacy, representing a promising therapeutic strategy against ...
PD-L1 is a novel direct target of HIF-1a, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med. 2014;211:781–90. Article CAS PubMed PubMed Central Google Scholar Muz B, de la Puente P, Azab F, et al. The role of hypoxia in cancer progression, ...
We also demonstrate that splenic myeloid cells acquire MDSC-like function in a HIF-1±-dependent manner. HIF-1± is also involved in driving the polarization towards M2-like macrophages and rendering intermediate stage monocytes more susceptible to L. donovani infection. Our results suggest that ...
It is also likely that many other complex factors such as the presence and activation states of other immune microenvironmental cells (such as macrophages, MDSCs, dendritic cells, and regulatory T cells), antigen presentation and the presence or absence of co-activating or inhibitory ligands by ...