(2001). Reduced HIC-1 gene expression in non-small cell lung cancer and its clinical significance. Anticancer Research, 21(1B), 535-540.Hayashi M, Tokuchi Y, Hashimoto T, Hayashi S, Nishida K, Ishikawa Y, et al. Reduced HIC-1 gene expression in non-small cell lung cancer and its ...
cells,and the convergence ofteamwasabout70 percent ofthecontrol group,the morphologicchanges incellswasno significant. Conclusion 1、Aberrant methylation ofthe HIC-l gene seemsto bean important mechanism underlying its down-regulation of expression. ...
Background:Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hyperme...
HIC-1基因在宫颈癌Hela细胞中的表达和其甲基化调控 中南大学 硕士学位论文 HIC-1基因在宫颈癌Hela细胞中的表达及其甲基化调控 姓名：刘雅琼 申请学位级别：硕士 专业：妇产科学 指导教师：陶光实 20080501
proteins, are known to participate as transcription factors in gene expression and in many cellular functions such ascell adhesion, motility andsignal transduction. The BRCT domain binds CtIP and interacts with theLIM domain proteinLMO4, thus forming a complex that was suggested to negate the ...
HIC1 inhibits HIV-1 gene transcription and the viral expression in microglial cells. We have pre- viously shown that CTIP2 favors the establishment and the persistence of HIV-1 latency in microglial cells, the central nervous system major reservoirs of the virus31. To decipher the role of...
We conclude that HIC1 is a candidate tumor-suppressor gene for which loss of function in both mouse and human cancers is associated only with epigenetic modifications.doi:10.1038/ng1077Chen, Wen YongZeng, XiaobeiCarter, Mark G.Morrell, Craig N....
Physical and Transcriptional Mapping of the 17p13.3 Region That Is Frequently Deleted in Human Cancer Within the latter region, Hypermethylated in Cancer 1 (HIC1) is located, a likely candidate for a tumor suppressor gene that has also been suggested to... C Hoff,P Seranski,J Mollenhauer,....
(miRNAs) has emerged as a major regulator of the initiation and progression of human cancers, including breast cancer.3,4 MiRNAs bind target mRNAs at complementary sites in their 3′-untranslated regions (3′-UTRs), thereby suppres- sing the expression of the target gene at the post- ...
siRNAsinhibitproliferationandinduceapoptosisofSiHaeervical cancercells.ChinJCancerRes.2oo8.20:301-306. 191DuanZ,BrakoraKA,SeidenMv.InhibitionofABCB1(MDR1) andABCB4fMDR3) expressionbysmatlinterferingRNAand reversalofpaclitaxelresistanceinhumanovariancancercells.Mol ...