EpigeneticsHIC1CIITADNMTDifferentiation of B lymphocytes into isotope-specific plasma cells represents a hallmark event in adaptive immunity. During B cell maturation, expression of the class II transactivator (CIITA) gene is down-regulated although the underlying epigenetic mechanism is not completely ...
Yoshihisa Watanabe, Masato Maekawa, in Epigenetics in Human Disease, 2012 2.2.4 Bisulfite Treatment and PCR Single-Strand Conformation Polymorphism (SSCP) (BiPS) The combination of bisulfite treatment with PCR-based single-strand DNA conformation polymorphism (SSCP) analysis offers a potentially quantitat...
epigeneticsHIC1transcriptional repressiontumor suppressor genesIntroduction: The tumor suppressor gene HIC1 (Hypermethylated in Cancer 1), which encodes a transcriptional repressor with multiple partners and multiple targets, is epigenetically silenced but not......
epigeneticsepithelial ovarian cancerAccumulated evidence revealed that aberrant CpG island hypermethylation plays an important role in carcinogenesis which can serve as a promising target for molecular detection in body fluids. Despite a myriad of attempts to diagnose ovarian cancer (OC) at an early ...
epigeneticsGWASHarnessing the power of single-cell genomics technologies, single-cell Hi-C (scHi-C) and its derived technologies provide powerful tools to measure spatial proximity between regulatory elements and their target genes in individual cells. Using a global background model, we propose Snap...