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genome-wide association studieswere first used in the early 2000s, coincident with the completion of the Human Genome Project and theInternational HapMap Projectand with the development of computer databases capable of storing the full human genome sequence and known variations, with the aim of ...
The genotype-phenotype mapping of proteins is a fundamental question in structural biology. Proteins possess flexible structures that allow them to adapt to the environments and perform their dynamics related to biological functions. Meanwhile, the mutations in protein sequences may lead to variations in...