Sign in to download full-size image Fig. 2.Example of a CpG island within the PPARα gene. The image shows the location, structure, and nucleotide sequence of part of the gene along with transcription factor binding sites. Note how the CG dinucleotides within the CpG island are separated by...
Sign in to download full-size image Fig. 1.Structures of the human MBD1 protein and the EGFP-MBD-NLS probe. (A) Domain structures of human MBD1. MBD, NLS, three CXXC domains and TRD. (B) Comparison of deduced amino acid sequences of human (upper) and mouse (lower) MBD1. (...
Rajiv P Sharma*,1, David P Gavin1 and Dennis R Grayson1 1The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago, IL, USA The study of CpG methylation of genomic DNA in neurons has emerged from the shadow of cancer biology into a fundamental investigation of ...
nature communications biology articles article Article Open access Published: 08 April 2023 High-resolution Nanopore methylome-maps reveal random hyper-methylation at CpG-poor regions as driver of chemoresistance in leukemias Alberto Magi, Gianluca Mattei, Alessandra Mingrino, Chiara Caprioli, ...
(2015) 15:273 DOI 10.1186/s12879-015-1016-7 RESEARCH ARTICLE CpG DNA analysis of bacterial STDs Martin Singer1†, Dewi J de Waaij1†, Servaas A Morré1,2 and Sander Ouburg1* Open Access Abstract Background: Bacterial infections in the genital tract frequently result in morbidity ...
Full size image Regulatory role of Sp1 on Podxl promoter activity The fragments up to the first 364 bp show a progressive increasing number of Sp1 sites, suggesting their role in transcription. To test this possibility we transfected some of the constructs into the Sp1-deficient Drosophila-derived...
Full size image It could be argued that methylation patterns change in a rather complex manner with several waves of methylation-demethylation events during development, so methylation profiles in other types of germline cells may also affect CpG > TpG substitution rates. On the other hand, th...
Full size image Increased apoptosis was observed in siRNA MeCP2 PC-3 cells as compared with control cells both at 5 and 7 days after the first transfection by Annexin V-FITC/propidium iodide staining (Figure 2B: compare B1-B2; B3-B4). In both conditions (siRNA CTRL and siRNA MeCP...
In subject area: Biochemistry, Genetics and Molecular Biology CpG islands are DNA regions in which a cytosine nucleotide occurs next to a guanine in the linear sequence of bases along its length. From: Interleukins in Cancer Biology, 2015 ...
Preventing or treating a disease: “Preventing” a disease refers to inhibiting the full development of a disease, for example in a person who is known to have a predisposition to a disease such as an autoimmune disorder. An example of a person with a known predisposition is someone with a...