Epigenetic memory is defined as the maintenance of gene expression states through cell generations in the absence of the initiating signals. PREs were first discovered in flies, in which they can mediate epigenetic memory of both silent and active states of their associated genes. Epigenetic memory ...
Differentiation is defined as a change in cell phenotype because of expression of genes associated with cellular function rather than cell division (Potten and Loeffler, 1990; Bach et al., 2000). Stem cells exhibit a wide range of differentiation potential. The zygote is totipotential, producing...
This clinical challenge is exacerbated by the pandemics of obesity, metabolic syndrome and type 2 diabetes. Diabetes prevalence is increasing in almost every country; globally, it is estimated that diabetes affects over 371 million people and costs US$471 billion [3]. However, the burden of diabe...
Mechanistic target of rapamycin (mTOR) is a protein kinase that upon can control multiple cellular processes upon intracellular and extracellular stimuli.Answer and Explanation: Since its mTORs discovery, extensive studies have been conducted both in yeast and animal species. mTOR was first identi...
Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data. Neuro Oncol 2018;20(2):184–191. doi:10.1093/neuonc/nox175. (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new window)Google Scholar...
Despite recent major advances in developing effective vaccines against toxoplasmosis, finding new protective vaccination strategies remains a challenging and elusive goal as it is critical to prevent the disease. Over the past few years, various experimental approaches have shown that developing an effectiv...
Methylation of CpG islands - which are found upstream of many genes - is regulated by the methyl-CpG-binding domain (MBD) family of transcriptional regulators. In Rett syn- drome, a disease unique to females, brain retardation has been found to correlate with lack of expression in the brain...
High performance computing (HPC) is one of the most impactful technologies used by scientists, researchers, and engineers to develop the most advanced and
What is a gene?A gene is a sequence of nucleotides that functions as the basic unit of heredity. Genes are passed on from parents to offspring and determine an individual's physical characteristics.Answer and Explanation: Gene expression is the process by which the information contained in a ...
This disease is caused by prenatal ethanol exposure and is characterized by lifelong physical and cognitive deficits, including impairments in executive functioning, social skills, and, notably, learning and memory. The authors focused on methyl CpG binding protein 2 (MeCP2) and H2A.Z in this ...