(G) INF-γ secretion in sera. The data were presented as means ± s.d. Statistical significance was calculated by one-way analysis of variance (ANOVA). (n = 5), *, P < 0.05; **, P < 0.01 Full size image CNPs enhanced the immunogenicity of tumor-derived antigens...
Full size image Determination of mMDP1 post- translational modification Our data shows that mMDP1 is more immunogenic than eMDP1. This could be due to post-translational modifications in mMDP1, which are absent in eMDP1. Although mAb 38–8 recognizes mMDP1 but not eMDP1 (Fig. 1D, right),...
The scale of inflammatory response relies on the ability of the host * Correspondence: s.ouburg@vumc.nl †Equal contributors 1Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands Full list of author information...
activators of TGF-b.48 More interestingly, there is a thrombospondin-1-like domain (domain 3, Figure 4e) existing in the full-length CCN1.18 Therefore, it is possible that CCN1 also induces IL-10 via a latent/indirect pathway via thrombospondin-1 domain-activated transforming growth factor b...
Full size image CpG-treated neutropenic animals that survived the infection show a delay in the clearance of bacteria After 14 days of infection, 45% (9/20) of the surviving neutropenic wt animals pre-conditioned with CpG ODN still showed positive bacterial cultures in cerebellum homogenates versus...
Check access to the full text by signing in through your organization. Access through your organization Section snippets Materials and methods Cell culture and plasmid constructs. HeLa cells were grown in DMEM medium (Gibco-BRL, Gaithersburg, MD). Cells were treated with 5 ng/ml Actinomycin D...
Journal of Medical GeneticsC. Spits, S. Seneca, P. Hilven, I. Liebaers, K. Sermon, Methylation of the CpG sites in the myotonic dystrophy locus does not correlate with CTG expansion size or with the congenital form of the disease, J. Med. Genet. 47 (2010) 700-703....
is a regulator of postnatal development. MDS was first described in a family of five males with neurodevelopmental delay[]. Previous studies involving Asian patients with MDS have shown that the clinical manifestations are similar to those in Western patients with MDS; however, most studies described...
Prophylaxis with unmethylated cytosine phosphate guanidine (CpG) oligodeoxynucleotides (ODN) protects against several systemic experimental infections. Escherichia coli is a major cause of Gram-negative neonatal bacterial meningitis and also causes menin
Download: Download full-size image Figure 2. DNA Fragment Immune Complexes Stimulate AM14 B Cells through a TLR-Dependent Mechanism (A) Proliferation of AM14 B cells in response to ICs formed between varying concentrations of a NIP-conjugated DNA fragment containing 50 immunostimulatory CpG motifs ...