amination, N‐alkylation, N‐arylationA new simple approach to the synthesis of unsymmetrical ureas HetNC(O)NRR′ (HetNH = pyrrole, indole, carbazole; R, R′ = H, alkyl, aryl) has been explored, which involves the direct reaction of theN-phenoxycarbonyl derivatives of pyrrole, indole and ...
ChemInform Abstract: A Simple Direct Phosgeneless Route to N-Heteroaryl Unsymmetrical Ureas.pyrrole derivativesamination, N-alkylation, N-arylationThe approach to ureas (III), (V), and (VII) involves the direct reaction of N-phenoxycarbonyl derivatives of pyrrole, indole, and carbazole, (I), (...
O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides of the general structural Formula I: have been prepared from suitable precursors by alkylation and/or arylation at C-3'' and/or C-4'' of the cyclohexyl ring. These macrolide immunosuppressants are useful in a...
摘要: The title compounds are prepared by Pd-catalyzed N-arylation of the sulfonamide and subsequent deprotection.关键词: sulfonamides (hydrazides, ureides) (benzene compounds amines (benzene compounds general (heterocyclic compounds amination, N‐alkylation, N‐arylation ...
Cu-catalyzed direct alkylation of 1,3-azoles with N-tosylhydrazones bearing ferrocenyl group. Recently, the Cu(I)-catalyzed regioselective C–H functionalization of azine N-oxides with N-tosylhydrazones was achieved under microwave conditions, giving rise to ortho-alkylated heterocyclic compounds (Scheme...
Arend, N. Risch Aminoalkylation of electron-rich aromatic compounds using performed iminium salts derived from aldehydes other than formaldehyde Synthesis, 7 (1996), pp. 883-887 View in ScopusGoogle Scholar [26] J.H. Wynne, W.M. Stalick Synthesis of 3-[(1-Aryl)aminomethyl] indoles J. ...
An efficient and reusable Cu_2O/PPh_3/TBAB (n-Bu_4NBr) system for the cross-coupling reactions of aryl and heteroaryl halides with terminal alkynes has been developed. Four types of Cu_2O, including bulky Cu_2O, cubic Cu_2O nanoparticles, octahedral Cu_2O nanoparticles, and spherical ...
An efficient Friedel–Crafts alkylation for the synthesis of 3-indolyl-3-hydroxy oxindoles and unsymmetrical 3,3-diaryl oxindoles catalyzed by Dabco-based ionic liquids in water A convenient and rapid method for the syntheses of 3-indolyl-3-hydroxy oxindoles and unsymmetrical 3,3-diaryl oxindole...
In those cases where the final product will contain a quaternized heterocyclic group, an additional alkylation step would be added. Method j ##STR67## EXAMPLE 3 Utilizing the procedures of Examples 1-2, the following externally alkylated compounds listed in Table I are prepared, wherein R1 ...
amination, N-alkylation, N-arylation; fused pyrimidine derivatives; benzothiazole derivatives; general (heterocyclic compounds); amines (benzene compounds); microwave chemistry, sonochemistry, mechanochemistry Abstract A broad variety of hetarylamines and anilines reacted with 2-trichloro-4-chloroquinazoline ...