N-Heteroaryl, N-alkylheteroaryl, N-alkenylheteroaryl and N-alkynylheteroaryl macrolides of the general structural Formula I: have been prepared from suitable precursors by amination, alkylation and/or arylation at C-3'' and/or C-4'' of the cyclohexyl ring. These macrolide immunosuppressants are ...
Alkylation of heteroaryl halides by 2:1 Grignard reagent/copper(I) mixtures. Synthesis of alkylated octahydrodibenzo[b,j][1,10]phenanthrolines Z represents an optionally substituted aryl or heteroaryl group; R1 represents hydrogen, hydrocarbon, a heterocyclic group, halogen, cyano, trifluoromethyl, ....
A subsequent sequence of hydrolysis and N/O-alkylation processes, respectively, afforded the starting quinoline-/quinolone aldehydes 6{1–7} in 70–85% yield as described previously [54] (Scheme 4). Additionally, a chemset of hydroxycoumarins 7{1–4} (Scheme 5) was chosen as the second ...
amination, N-alkylation, N-arylationChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.doi:10.1002/chin.200649101...
amination, N‐alkylation, N‐arylationpyrazole derivativespyridine derivativespyrimidine derivativescatalysis, phase‐transfer catalysisHeteroaryl-substituted arenes and heteroarenes are efficiently amidated through ruthenium-catalyzed C—H bond functionalizations with a variety of sulfonyl azides.doi:10.1002/chin....
Preliminary mechanistic studies suggest this atom-economic reaction proceeds through an enantioselective dimerization of isoprene and a sequential C–H alkylation of heterocycles pathway. This work not only contributes an efficient enantioselective transformation of bulk chemical isoprene, but also provides a ...
A general, mild, and chemoselective one-pot oxidation/imine-iminium formation/nucleophilic addition sequence allowing the N-alkylation of amines by alcohol... C Guérin,V Bellosta,G Guillamot,... - 《European Journal of Organic Chemistry》 被引量: 34发表: 2012年 trans-Cyclopentane-1,2-diamine...
Sterically Controlled Alkylation of Arenes through Iridium‐Catalyzed CH Borylation A mild method to prepare aryl and heteroaryl iodides by sequential C-H borylation and iodination is reported. The regioselectivity of this process is contr... DW Robbins,JF Hartwig - 《Organic Letters》 被引量: 108...
According to Scheme 1, compounds of the general formula I may be prepared by alkylation of an intermediate of formula VI with a compound of the general formula R4 --(CR23 R24)p --Y wherein Y is a leaving group such as chloro, bromo, iodo, --OSO2 Ph, --OSO2 PhCH3, --OSO2 CH3...
ChemInform Abstract: A Simple Direct Phosgeneless Route to N-Heteroaryl Unsymmetrical Ureas.pyrrole derivativesamination, N-alkylation, N-arylationThe approach to ureas (III), (V), and (VII) involves the direct reaction of N-phenoxycarbonyl derivatives of pyrrole, indole, and carbazole, (I), (...