Transcriptional activity of HERV-K(HML-2) has been studied by different approaches (for instance, see [30,49,50,51,52,53,54]). HML-2 transcripts can be identified in a number of tissue and cell types (see above), and there have been various attempts to identify the actual transcribed ...
HERV-K (HML-2) proviruses have been classified by the presence (type 1) or absence (type 2) of a 292 bp deletion at thepol-envjunction [13]. Type 2 proviruses encode the accessory protein Rec, involved in the transport of unspliced mRNAs from the nucleus to the cytoplasm and analogou...
Direct activation of NTRK3 phenotypically resembles HERV-K(HML-2) induction, and reducing NTRK3 levels in context of HERV-K(HML-2) induction restores cortical neuron differentiation. Hence, these findings unravel a cell-type-specific role for HERV-K(HML-2) in cortical neuron development. ...
Recently, we reported an almost intact human endogenous retrovirus (HERV-K(HML-2.HOM); HGMW-approved symbol ERVK6) located on human chromosome 7, with open reading frames for all retroviral genes and a mutation only within the reverse transcriptase. We further characterized the genomic organizati...
BackgroundIncreased transcription of the human endogenous retrovirus group HERV-K (HML-2) is often seen during disease. Although the mechanism of its tissue-specific activation is unclear, research shows that LTR CpG hypomethylation alone is not sufficient to induce its promoter activity and that the...
12 weeks after the end of treatment. Our results show that HERV-K(HML-2) levels are strongly associated with albumin levels and the presence of liver cirrhosis in HCV-positive patients. Moreover, HERV-K(HML-2) levels were increased in patients who did not achieve a sustained viral response...
The HERV-K(HML-2) family contains the most recently integrated and best preserved endogenized proviral sequences in the human genome. All known elements have nevertheless been subjected to mutations or deletions that render expressed particles non-infectious. Moreover, these post-insertional mutatio...
Viruses 2014, 6(11), 4332-4345; https://doi.org/10.3390/v6114332 ActionDateNotesLink article pdf uploaded. 11 November 2014 10:42 CET Version of Record https://www.mdpi.com/1999-4915/6/11/4332/pdf article xml file uploaded 28 November 2014 11:05 CET Original file https://www.mdpi....