HERV-K envelope proteinmitochondrial dysfunctionneurotoxicityreactive oxygen speciesHuman endogenous retroviruses (HERVs) are associated with the pathogenesis of amyotrophic lateral sclerosis (ALS); a disease characterized by motor neuron degeneration and cell death. The HERV-K subtype HML-2 envelope protein...
HERV-K(HML-2) has been associated with neurotoxicity, but there is no clear understanding of its role or mechanistic basis. We addressed the physiological functions of HERV-K(HML-2) in neuronal differentiation using CRISPR engineering to activate or repress its expression levels in a human-...
Type 1 and type 2 HERV-K(HML- 2) viral RNA genomes were found to coexist in the same plasma of HIV-1 patients. These results suggest the HERV-K(HML-2) viral particles are induced in HIV-1-infected individuals. 展开 年份: 2006 ...
The HERV-K clade of betaretrovirus-like endogenous retroviruses contains ten groups (HML-1-10) that are most closely related to mouse mammary tumor virus (MMTV), a causative agent for breast cancer in mice [10]. The most recently active retroviruses belong to the HML-2 group, which has be...
Recently, we reported an almost intact human endogenous retrovirus (HERV-K(HML-2.HOM); HGMW-approved symbol ERVK6) located on human chromosome 7, with open reading frames for all retroviral genes and a mutation only within the reverse transcriptase. We further characterized the genomic organizati...
Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 replication
BackgroundIncreased transcription of the human endogenous retrovirus group HERV-K (HML-2) is often seen during disease. Although the mechanism of its tissue-specific activation is unclear, research shows that LTR CpG hypomethylation alone is not sufficient to induce its promoter activity and that the...
HERV-K(HML-2), the best preserved family of HERVs: endogenization, expression, and implications in health and disease. Front Oncol. 2013;3:246. Article PubMed PubMed Central Google Scholar Downey RF, Sullivan FJ, Wang-Johanning F, Ambs S, Giles FJ, Glynn SA. Human endogenous retrovirus...
机译:HERV-K(HML-2)原病毒衍生序列的启动子表达与LTR序列变异和多态性转录因子结合位点有关 7. 4-5 ヒト内在性レトロウイルスHERV-KのLTRにみる進化的変化(X.共同利用研究 2.研究成果) [O] . 加藤 伊陽子 2009 机译:4-5人类内源性逆转录病毒HERV-K LTR的进化变化(X.联合研究2.研究结果) AI...
HERV-K: Human endogenous retrovirus-K (HML-2) RIN: RNA integrity number RNA-Seq: Whole transcriptome shotgun sequencing by next-generation sequencing RT-qPCR: Quantitative real-time reverse transcription polymerase chain reaction XPNPEP1 : X-prolyl aminopeptidase 1 gene (reference transcript us...