Chaudhary LN, Jorns JM, Sun Y, et al. Frequent upregulation of HER2 protein in hormone-receptor-positive HER2-negative breast cancer after short-term neoadjuvant endocrine therapy. Breast Cancer Res Treat. 2023;201(...
Conclusion Selection of HER2/NEU negative tumor cells may represent a major mechanism of resistance to trastuzumab in USC patients.doi:10.1016/j.gore.2020.100554Silvia Pelligra aNatalia Buza bPei Hui bStefania Bellone aBurak Zeybek aElena Ratner a...
[3]Sanford RA, Song J, Gutierrez-Barrera AM, et al. High incidence of germline BRCA mutation in patients with ER low-positive/PR low-positive/HER-2 neu negative tumors[J]. Cancer, 2015, 121(19):3422-3427. [4]Allison KH, Hammond MEH, Dowsett M, et al. Estrogen and Progesterone Rec...
[11]Kurozumi S,et al.HER2 intratumoral heterogeneity analyses by concurrent HER2 gene and protein assessment for the prognosis of HER2 negative invasive breast cancer patients.Breast Cancer Res Treat 2016;158:99–111. [12]Parker JS,et al.Supervised Risk Predictor of Breast Cancer Based on Intrins...
[17] Scott M, Vandenberghe M, Scorer P, et al. Prevalence of HER2 low in breast cancer subtypes using the VENTANA anti-HER2/neu (4B5) assay. 2021 ASCO.1021. [18] Corgiat B, O'Shaughnessy J, LoRusso P, et ...
her2/neu有关癌基因的例句:1.If the cancer tests negative for over-expression of the her2/ neu oncogene, weekly chemotherapy with taxol or taxotere is an effective option with acceptable side effects. 如果发现癌基因her2/neu表达降低，那么每周一次的化疗和紫杉烷类或泰索帝一起使用疗效显著，...
DESTINY-Breast04(DB-04)研究阳性结果的公布具有里程碑意义,首次证实新型抗体偶联药物(ADC)T-DXd用于经治的HER2低表达(HER2-Low)晚期乳腺癌患者,可带来PFS和OS双重显著获益,而且不论HR状态、是否经过CDK4/6抑制剂(CDK4/6i)、是否快速进展、是否存在内脏转移等各亚组患者均有获益。T-DXd在HER2低表达的获...
HER2由ERBB2（又称Neu）基因编码，该基因定位于17号染色体的17q21，编码一个相对分子量为185kDa的酪...
Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cellsGeradts J., Leek R Harris A L Wilson K S
Human epidermal growth factor receptor 2 (HER2-neu) is an important prognostic factor associated with worsened disease-free survival and overall survival in breast cancer patients; however, the prognosis of T1a,b,N0,M0 HER2-neu positive breast cancer has not been clearly determined. Trastuzumab has...