C4 QUEST studies [FDA approved (GT-1)] D1 Study AI444040 (GT1,2,3,4) FDA-approved GT-1,GT-3 D2 Daclatasvir NS5A 60 mg EMCUPc (GT1,2,3,4)-ALLY-1 (GT-1)d D4 COMMAND-4 Paritaprevir NS3 150 mg E1e Ritonavir CY450 100 mg PEARL-1 (GT4) , RUBY-1 (GT1) Ombitasvir...
Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): A phase 3, randomised, double-blind, placebo-controlled trial Lancet, 384 (2014), pp. 403-413 Google Scholar 144 M. Manns, P. Marcellin, F....
including HBV viral load, alanine aminotransferase (ALT), and hepatitis B core-related antigen (HBcrAg). Given that ALT and HBcrAg are both protein biomarkers, they can be easily incorporated into our current HBV protein biomarker panel. HBV viral load ...
The participants received Quest Diagnostics’ obstetric testing panel. Overall, across the study population, 23% had an HCV screening test. But during the 2011 to 2021 study period, the screening rate rose by 145%, from 17% at the beginning to 41% at the end. Although the increase in scre...
validated in a blind fashion in the Alter panel, yielding positive results in six of seven sera from patients with NANBH, whereas all control sera from healthy individuals tested negative. Notably, the negative result was obtained in a patient assumed to be in the very acute phase of ...
Hepatocellular carcinoma (HCC), a major cause of cancer death in China, is preceded by chronic hepatitis and liver cirrhosis (LC). Although hepatitis B virus (HBV) has been regarded as a clear etiology of human hepatocarcinogenesis, the mechanism is stil
be achieved without a substantial increase in the rate of HBV diagnosis. It is estimated that less than 10% of individuals with HBV infection have been identified, and only 10% of the eligible patients receive treatment globally12. To achieve the goal set by WHO, a panel of serum biomarkers...
judged to be 10–20 years hence. Reducing the regional impact of this disease should be a major goal of governments in the Asian-Pacific region and this aim increases the urgency with which treatments should be made available. Of course, to have any impact on HCV-related disease burden, ...
Insights into the immunopathogenesis of chronic HBV infections are fundamental in the quest for novel treatment approaches aimed at a functional cure. While much is known about the ineffective HBV-specific T-cell responses that characterise persistent HBV replication, B cells have been left largely und...
Populations of cells containing subdiploid DNA content were quantified according to the DNA contents of the cell using Becton–Dickinson Cell Quest software. An average of 104 cells was used in each experiment. Caspase assays Caspase 3 and 8 activities were assayed using calorimetric substrates of ...