C4 QUEST studies [FDA approved (GT-1)] D1 Study AI444040 (GT1,2,3,4) FDA-approved GT-1,GT-3 D2 Daclatasvir NS5A 60 mg EMCUPc (GT1,2,3,4)-ALLY-1 (GT-1)d D4 COMMAND-4 Paritaprevir NS3 150 mg E1e Ritonavir CY450 100 mg PEARL-1 (GT4) , RUBY-1 (GT1) Ombitasvir...
including HBV viral load, alanine aminotransferase (ALT), and hepatitis B core-related antigen (HBcrAg). Given that ALT and HBcrAg are both protein biomarkers, they can be easily incorporated into our current HBV protein biomarker panel. HBV viral load ...
which frequently took a chronic, progressive course and could be attributed neither to the hepatitis A virus (HAV), the hepatitis B virus (HBV) nor to any other known cause. This phenomenon was called non-A, non-B hepatitis (NANBH). It took approximately 20 years until the hepatitis C v...
Simeprevir with pegylated interferon alfa 2a or 2 b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): A randomised, double-blind, placebo-controlled phase 3 trial Lancet, 384 (2014), pp. 414-426 Google Scholar 145 X. Forns, E. Lawit...
Hepatocellular carcinoma (HCC), a major cause of cancer death in China, is preceded by chronic hepatitis and liver cirrhosis (LC). Although hepatitis B virus (HBV) has been regarded as a clear etiology of human hepatocarcinogenesis, the mechanism is stil
Hepatitis B Virus (ICE-HBV) held a virtual and interactive workshop on HBV biomarkers endorsed by the International HBV Meeting. Various stakeholders from academia, clinical practice and the pharmaceutical industry, with complementary expertise, presented and participated in panel discussions. The ...
1b had virological breakthrough, while the other two, one with HCV GT-1a and one with HCV GT-1b, had virological relapse. Concerning HCV NS5A-resistant associated variants (RAVs), the relapser with HCV GT-1a had the L31M variant, and both patients with HCV GT-1b had the Y93H ...
Insights into the immunopathogenesis of chronic HBV infections are fundamental in the quest for novel treatment approaches aimed at a functional cure. While much is known about the ineffective HBV-specific T-cell responses that characterise persistent HBV replication, B cells have been left largely und...
1B). Cells expressing truncated core protein by infection with dsSIN:core152 did not induce apoptosis above the control cells at this time point, but by 48 h had significant levels of apoptosis (28%) above the control, CAT-expressing cells (6%). Download: Download full-size image Fig. 1...
First, we generated a panel of inferred germline precursors (gl) of AR3C-class bNAbs: AR3A, AR3B, AR3C, AR3D, HEPC3, HEPC74, and AT1209. Most inferred germline sequences were published previously32,43, while the others were computationally inferred using IMGT/V-QUEST software, a tool ...