However, the real-life HCV-TARGET observational study [10] has reported acute deterioration of kidney function with Sofosbuvir-based treatment protocols in 5/17 patients (29%) with eGFR <30 mL/min/1.73 sqm, 6/56 patients (11%) with eGFR 30–45 mL/min/1.73 sqm, compared to 14/1559 ...
Protecting the function of lymphocytes during acute infection is likely to be important, with studies suggesting that patients with strong Th1 CD4+ and more vigorous CTL responses have an improved ability to clear this virus Lechmann et al 1996, Nelson et al 1997, Rehermann et al 1996a. The ...
Rognant N, Lemoine S (2014) Evaluation of renal function in patients with cirrhosis: where are we now? World J Gastroenterol 20:2533–2541 PubMedPubMed CentralGoogle Scholar De Nicola L, Zoccali C (2016) Chronic kidney disease prevalence in the general population: heterogeneity and concerns. ...
The increasing number of reports that treatment with the new DAAs are well tolerated and efficacious in patients with decompensated cirrhosis and, more importantly, markers of hepatic and synthetic function improved during the short-term follow-up [94,95], will be reviewed. The inclusion of these ...