Repeatedly reactive sam- ples can be considered positive for antibodies to HAV andtherefore there are indications for past or current infectionwith hepatitis A virus.Borderline (S/CO =0.9-1.1): Samples with absorbance toCut-off ratio between 0.9 and 1.1 are considered borderline. Retesting of ...
(25–65) years) with anti-hepatitis A virus antibody titres ≤20 IU/L (maximally 17 IU/L) were given a single dose of 0.5 mL of the IRIV hepatitis A vaccine 1 to 14 (mean 9.4) years after splenectomy. Immediately after the immunisation and 14 and 28 days afterwards the anti-HAV ...
The hepatitis A virus is found predominantly in the stools (feces) of people with hepatitis A. HAV is transmitted when a person puts something in his or her mouth that has been contaminated with the feces of an affected person. This is referred to as fecal-oral transmission. However, variat...
It is postulated that a drug, virus, or an environmental agent can trigger a T-cell-mediated cascade directed against liver antigens in genetically susceptible individuals who are prone to autoimmune disease. Table 23.7. Interpretation of HCV Test Results Immunoassay (HCV Antibody)Recombinant ...
H epatitis C virus (HCV) is a single-stranded RNA virus belonging to the Flaviviridae family1. HCV infects 3.0% of the world's population and is a major cause of liver disease worldwide2. HCV infection progresses to chronicity in 70%–85% of infected adults3. An estimated 476,000 ...
Summary. Stored serum samples from 24 blood donors confirmed positive for anti-HIV-1 were tested for antibody to hepatitis C virus (HCV). Those repeatedly reactive using the anti-HCV ELISA screening test were retested by the HCV recombinant immunoblot (RIBA). Risk-factors for the contraction of...
A self-adjuvanting multiepitope immunogen that induces a broadly cross-reactive antibody to hepatitis C virus We describe a peptide-based strategy for HCV vaccine design that addresses the problem of variability in hypervariable region 1 (HVR1). Peptides representing antibody epitopes of HVR1 from ...
摘要: Two patients with acute liver dysfunction who were negative for serum IgM-HA antibody on presentation became positive a week later. At early stages of hepatitis A, serum IgM-HA antibody may be negative. Another assay approximately 2 wk apart is recommended....
OBJECTIVES: In the present study, we aimed to determine whether signal-to-cutoff (S/Co) ratios of reactive anti-HCV samples could be used as a basis for avoiding the need for supplemental testing in our study population. METHODS: We analyzed 901 anti-HCV-positive sera from 8 institutions in...
Hepatitis B surface antigen (HBsAg) indicates either acute or chronicHBVinfection. People with positiveHBsAgare infectious and can transmit the virus to others. The IgM subclass of antibody to thehepatitis B core antigen(IgM anti-HBc) indicates acute infection while total IgG anti-HBc is a nonspe...