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We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
Therefore, despite its abundance, ERα accomplishes a significant metabolic function in the male liver that is clearly not the same as in females. This is particularly relevant with regard to the uptake and de novo synthesis of lipids; indeed, under HFD conditions, the regulation of genes ...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
An intrinsically disordered domain has a dual function coupled to compartment-dependent redox control. J Mol Biol 2013;425:594–608. 24. Allen S, Balabanidou V, Sideris DP, et al. Erv1 mediates the Mia40- dependent protein import pathway and provides a functional link to the respiratory ...
In mammals, there are many factors influencing hepatic β-oxidation via changing function and enzyme activity, such as feed intake, feed ingredient, physiological condition, lipid production, the content of malonyl-coenzyme A, or liver fatty acid composition (Kabir and Ide, 1996; Sleboda et al.,...
It is important to distinguish tests of liver damage (like enzymes) versus tests of liver function (like bile acids). The enzymes ALT and AST are normally held inside liver cells; when their presence is detected free in the bloodstream, this is an indicator of liver cell death. A liver ca...
function of microvilli relies on the continual polymerization and depolymerization of actin microfilaments, and both cofilin and HSP27 play important roles in F-actin dynamics[12,34,35]. The down-regulation of cofilin and F-actin indicated that the function of bile canaliculi was also impaired ...
to define HSC function and the mechanism of its action during fatty inflammation of the liver by identifying HSC-secreted mediators that have profound effects on nearby hepatocytes. In healthy humans and mice, HSCs are quiescent, residing near sinusoids in the space of Disse. However, once the ...
Structure prediction is important to characterize the function of the protein. The mature peptide of hepcidin has a beta hairpin structure in which the two arms are linked by disulphide bond in ladder-like manner [11]. The mature region of Cc-Hep shows two antiparallel beta sheet stabilized by...