Therefore, despite its abundance, ERα accomplishes a significant metabolic function in the male liver that is clearly not the same as in females. This is particularly relevant with regard to the uptake and de novo synthesis of lipids; indeed, under HFD conditions, the regulation of genes ...
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Class 3 semaphorins (SEMA3A-G) play a major role in various biological processes and human disorders, including neural and cardiovascular development, adipogenesis, adipose tissue function, hypothalamus regulation of obesity, inflammation and energy balance18,19,20. SEMA3A is a secreted protein and bi...
Thus, the hepatic environment is required to maintain a tight balance between pathogen clearance during infections and inflammatory responses, which may cause hepatocyte cell death and loss of liver function. Here, we sought to elucidate the role of LRH-1 in inflammation-driven hepatic cell death ...
Ectopic expression and functions of odorant receptors (ORs) in the human body have aroused much interest in the past decade. Mouse olfactory receptor 23 (MOR23, olfr16) and its human orthologue, OR10J5, have been found to be functionally expressed in sev
Especially in case of CI-induced model, the TLR2 expression was prominent at the border edge of the wound, the area which characterized abundant expression of SAA1 and the deployment of HSCs (lower right panel in Figure S1B). This injury-induced molecular and cellular spatiotemporal appearing ...
3-ketodihydrosphingosine reductase (KDSR) is the key enzyme in the de novo sphingolipid synthesis. We identified a novel missense kdsrI105R mutation in zebrafish that led to a loss of function, and resulted in progression of hepatomegaly to steatosis, th
We also tested the function of SPP1 for LyECs in vitro. We found that SPP1 increased the proportion of dead LyECs significantly, and that SPP1 treatment damaged the tube formation ability of LyECs in a dose- and time-dependent manner. Taken together, our data suggested that during the ...
Dark gray dots represent cells that were negative for all the markers in the multiplex panel. (E) The same exported multicomponent TIFF files used in Figure 1D were used by the Visiopharm phenotype matrix algorithms to determine the different cellular phenotypes present in each of the 20× ...