Thus, the hepatic environment is required to maintain a tight balance between pathogen clearance during infections and inflammatory responses, which may cause hepatocyte cell death and loss of liver function. Here, we sought to elucidate the role of LRH-1 in inflammation-driven hepatic cell death ...
in vivofunction of KDSR has been under-studied due to the lack of an animal model. We found progression of liver disease phenotype in thekdsrmutant zebrafish and we investigated the mechanism of disease pathogenesis in this paper. Given the well-conserved sphingolipid...
Blood was drawn from the abdominal aorta into an EDTA-coated tube, and plasma was separated by centrifuging the blood at 2000g for 15 min at 4 °C. The entire liver was dissected out, weighed, and snap-frozen in liquid nitrogen prior to storage at −70 °C. All animal ...
Of particular interest, in this regard, is serum amyloid A (SAA), one of several acute phase proteins responsible for recruiting monocytes, immature dendritic cells, phagocytes, and blood leukocytes during an inflammatory response (Badolato et al., 1995; Gouwy et al., 2015; Liang et al., ...
Empyema has rarely been associated with hepatic abscess. In patients with concurrent empyema and hepatic abscess, hepatic abscess drainage is usually required after drainage of the pleura. We present a rare case of a 91-year-old Caucasian man who present
To obtain serum, blood was incubated at room temperature for 30 min and then centrifuged at 1200× g for 15 min at 4 °C. The liver, soleus muscle, and abdominal (epididymal, perirenal, and mesenteric) white adipose tissue (WAT) and brown adipose tissue were excised immediately and ...
Short-chain fatty acids in the blood may reduce oxidative stress and help maintain immune function [21]. They may also improve glucose metabolism and insulin secretion by inducing the secretion of gut hormones such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) [19]. Microbial ...
Adropin reduced body weight, size of adipocytes, blood levels of triacylglycerol and cholesterol in T2D mice. T2D mice treated with adropin had lower liver mass, reduced hepatic content of triacylglycerol and cholesterol. Furthermore, adropin attenuated elevated blood levels of hepatic enzymes (...
We also tested the function of SPP1 for LyECs in vitro. We found that SPP1 increased the proportion of dead LyECs significantly, and that SPP1 treatment damaged the tube formation ability of LyECs in a dose- and time-dependent manner. Taken together, our data suggested that during the ...
OMIP-069: Forty-Color Full Spectrum Flow Cytometry Panel for Deep Immunophenotyping of Major Cell Subsets in Human Peripheral Blood. Cytom. Part A 2020, 97, 1044–1051. [Google Scholar] [CrossRef] [PubMed] Subrahmanyam, P.B.; Maecker, H.T. CyTOF Measurement of Immunocompetence Across ...