Mechanistically, ACOT12 and ACOT8 are dramatically upregulated in the liver to convert free fatty acid-derived acetyl-CoA to acetate and CoA. This conversion not only provides a large amount of acetate, which preferentially fuels the brain rather than muscle, but also recycles CoA, ...
In patients with non-alcoholic fatty liver disease (NAFLD), it has been estimated that as much as 26% of the liver triglyceride derives from DNL (18). The first committed step in lipid synthesis is the conversion of acetyl-CoA to malonyl-CoA, catalyzed by acetyl-CoA carboxylase (ACC). ...
Influence of experimental diets on: Final weight (a), ADFI (b) and FCR (c) of piglets. ADFI—Average daily feed intake; FCR—feed conversion ratio. Control—control diet; SP—10% Spirulina diet; SP + L—10% Spirulina diet supplemented with lysozyme..a,bValues within a row with di...
Dietary fructose is converted to acetate by the gut microbiota9, and this supplies lipogenic acetyl-CoA independently of ACLY10. Depletion of the microbiota or silencing of hepatic ACSS2, which generates acetyl-CoA from acetate, potently suppresses the conversion of bolus fructose into hepatic acetyl...
3). FASN is responsible for the conversion of acetyl-coA into long-chain fatty acids. FASN mRNA levels were 182-fold higher in the posthatch D3 liver compared the E18 liver. FASN mRNA is a miR-107 target (Figs. 2 and 3d). MiR-107 is also known to function in insulin sensitivity ...
CoA, which is converted through fatty acid β-oxidation to acetyl-CoA with conversion of NAD+ to NADH, provides specificity for FAO [10]. The level of fatty acid oxidation is determined as the INT-formazan level in the presence of octanoyl CoA minus the level in the absence of octanoyl ...
vehicle contained 2% of ethanol, which is oxidized to acetate in the liver and on the other hand, it has been shown that fructose increases the rate of ethanol metabolism in both animals and man46, 47. Discriminant metabolites between HFS and HFS + C groups....
Furthermore, isotopomer labeling of citrate indicated increased incorporation from pyruvate-derived oxaloacetate and decreased conversion of labeled acetyl-CoA by PDH (Figure 4E). An alternative pathway for pyruvate is conversion to alanine, and although there were no changes in steady state alanine ...
Oxidative stress-induced lipid accumulation is mediated by lipid droplets (LDs) homeostasis, which sequester vulnerable unsaturated triglycerides into LDs to prevent further peroxidation. Here we identify the upregulation of lipopolysaccharide-binding pr
Glucose production and alanine conversion to glucose were in the low normal range when compared to normal children in the postabsorptive state. The hypoglycemia in our patients was probably due to a modest increase in glucose consumption, secondary to the decreased oxidation of fatty acids and ...