Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we...
仪器耗材:生物上游工艺,生物下游工艺,细胞治疗,微生物监测,理化分析,公用系统。 品牌服务: 生命科学: Abcam、AdooQ、ALPCO、Biolegend、Cytiva、Cayman、Dojindo、Immunostar、Invitrogen、Jackson、美天旎Miltenyi、Novoprotein近岸、Prozyme、R&D、SinoBiological义翘、Stratagene、SYSY、Thermo Fisher、Wako、Topoen ...
Acs irreversibly transforms acetate to acetyl-CoA, consuming ATP [6]. This is a high affinity pathway with a low Km for acetate (200 μM) and low Vm, and therefore suitable for metabolizing low concentrations of acetate [5]. When growing on glucose, it is expressed during the stationary ...
Acetate-CoA Ligase (Acetyl-CoA Synthetase),from yeast, lyophilizate 货号:10128180103 包装:U 品牌:Roche 罗氏 乙酰辅酶A合成酶,乙酰辅酶A连接酶;EC #/ CAS:EC 6.2.1.1;来源:from yeast, lyophilizate;
a·ce·tyl-CoA li·gase (as'ĕ-til lī'gās) A ligase that catalyzes the reaction of acetate and CoA and ATP to form AMP, pyrophosphate, and acetyl-CoA. A key step in the activation of acetate. Synonym(s):acetate thiokinase,acetate-CoA ligase,acetyl-activating enzyme,acetyl-CoA synthe...
RESEARCH HIGHLIGHTS M E TA B O L I S M Acetate nourishes stressed tumour cells Acetate is ligated to coenzyme A (CoA) by acetyl-CoA synthetases (ACSSs) to form acetyl-CoA, which can be used in fatty acid synthesis (lipogenesis) and in histone acetyl ation. Lipogenesis is required ...
Most is utilized within the cells or tissues where the acetate or acetyl-CoA is generated, some is transported to other tissues and utilized there. Absorption of acetate from the small intestine especially the jejunum, appears to proceed mainly via the proton/monocarboxylic acid cotransporter, which...
Respective enzymes (blue) have not been characterized yet, but are assumed to perform analogous reactions as for butyrate formation. Abbreviations: Ack, acetate kinase; Acs, acetyl-CoA synthase; Adh, alcohol dehydrogenase; AdhE, aldehyde/alcohol dehydrogenase; AldH, aldehyde dehydrogenase; Aor, ...
Two independent pathways in Escherichia coli convert acetate to acetyl CoA: reversal of acetate production by phosphotransacetylase and acetate kinase, and... Sooan,Shin,Suk,... - 《Fems Microbiology Letters》 被引量: 62发表: 2006年 Genetics of serine pathway enzymes in Methylobacterium extorquens...
(pyruvate dehydrogenase gene) was underexpressed inE. coliBL21 grown in glycerol, and its expression is activated by cAMP-Crp and repressed by Cra and ArcA [37]. Regarding to acetate metabolism,acs(acetyl-CoA synthetase gene) expression was upregulated inE. coliBL21 grown in glycerol and it ...