Warfarin was discontinued and she was switched to IV unfractionated heparin therapy [ dosage and duration of treatment not stated ], which was monitored using anti-Xa levels. Results showed an exponential increase in her PTT as her anti-Xa level exceeded 0.3 U/mL [ time to onset not stated ...
This study assessed the relationships between rivaroxaban-specific anti-factor Xa activity (AXA) and unfractionated heparin (UFH)-specific AXA and determined the cutoff level for UFH-specific AXA in critical situations for patients undergoing rivaroxaban therapy. Methods Thirty-eight blood samples were ...
Adjust heparin to maintain APTT of 60 to 85 seconds, assuming this reflects an anti-Factor Xa level of 0.35 to 0.70. 2.5 Cardiovascular Surgery Patients undergoing total body perfusion for open-heart surgery should receive an initial dose of not less than 150 units of heparin sodium per kilogra...
Low-molecular weight heparin (LMWH) is the product of enzymatic or chemical degradation of unfractionated heparin (UFH). It has been found to have better b... BKH Ip,AR Thomson,HT Moriarty - 《Pathology》 被引量: 31发表: 2001年 Anti-Xa stability of diluted dalteparin for pediatric use. ...
Although studies have shown that unfractionated heparin therapy is more strongly associated with anti-Xa activity, measurement of anti-Xa activity as a routine practice is not necessarily the standard of care due to lack of evidence1,2,3,4. Intensivists frequently have difficulty predicting ...
The discovery and clinical application of heparin have signifi-cantly improved the outcomes in numerous aspects of serious medi- cal conditions. In this light, several heparin-based agents, such as unfractionated heparin (UFH) and low molecular weight heparin (LMWH), are included in World Health...
heparin-induced thrombocytopenia”.Blood.vol. 108. 2006 Nov 1. pp. 2937-41.(A pooled analysis of seven prospective studies demonstratinga greater incidence of HIT in females than in males and a greater risk of HIT associated with use of unfractionated heparin than...
As a consequence, higher doses of dp12 were required to produce a similar level of anti-Xa activity in blood. This can be explained in terms of the relative length of the molecules. It is known that specific pentasaccharide sequences are required for AT binding; these motifs are present ...
tauD UDP-glucose-dehydrogenase TriS trisulfate UDP uridine 5’-diphosphate UDP-GlcA UDP-glucuronic acid UDP-GlcNAc UDP-N-acetylglucosamine UFH unfractionated heparin ULMWH ultra-low-molecular-weight heparin USP United states pharmacopeia WHO World health organization Xyl xylose XylT xylosyltransferase. ...
50 Owing to their lighter weight compared with unfractionated heparin, LMWHs exhibit antithrombin III–dependent coagulation factor inactivation but also significant anti–factor Xa activity. LMWH activity may be assessed using an anti–factor Xa assay, available in many hospital clinical laboratories.51...