In this so called heparin resistance, measurement of anti-Xa activity is recommended over APTT to avoid potentially harmful dose escalation. A combination of anti-Xa measurement and global hemostatic testing with ROTEM employing the anti-Xa sensitive PiCT reagent showed high correlation with enoxaparin...
Although studies have shown that unfractionated heparin therapy is more strongly associated with anti-Xa activity, measurement of anti-Xa activity as a routine practice is not necessarily the standard of care due to lack of evidence1,2,3,4. Intensivists frequently have difficulty predicting ...
We aimed to identify attributing factors to the interindividual variabilities of the infusion rates in unfractionated heparin therapy. We included patients who required unfractionated heparin therapy to achieve the target APTT after cardiac surgery betwe
Monitoring of unfractionated heparin in critical ill ICU patients: a prospective study comparing aPTT and point-of-care viscoelastic testing with IN /HI ratio to anti-Xadoi:10.1055/s-0042-1760501Heubner, LDietze, ATiebel, OGüldner, AVicent, O...
The development of efficient production of unfractionated heparin (UFH) preparations, which are widely used in clinical practice, is currently a critical problem. According to WHO guidelines, specific and selective methods for monitoring heparin activity in preparations and substances must be used in ...
The effect of unfractionated heparin, enoxaparin, and danaparoid on lupus anticoagulant testing: Can activated carbon eliminate false‐positive results?doi:10.1002/rth2.12264Pieter M De KeselKatrien Devreese
Unfractionated heparin (UFH)Monitoring of anticoagulant activity of unfractionated heparin (UFH) is primarily done with activated partial thromboplastin time (aPTT), which is affected by many factors. Anti-Xa assays are considered to overcome these factors and may provide a better method for monitoring...
While the differences were minimal in the anti-Xa and anti-IIa assays, marked differences were noted in the aPTT and ACT. Thus, there is a need for additional testing to compare heparin preparation to assure minimal batch variations.doi:10.1096/fasebj.24.1_supplement.951.9Nasir Sadeghi...
Unfractionated Heparin Activity Testing in Preparations and Substancesunfractionated heparincoagulation methodstest systemsAPTT reagentsprocess controlThe development of efficient production of unfractionated heparin (UFH) preparations, which are widely used in clinical practice, is currently a critical problem. ...
Of the patients, two received low-molecular-weight heparin (LMWH) before the procedure, but this had no impact on the baseline ACT values (137 s and 149 s, ACT-LR median 142 s in all patients for the baseline) and anti-Xa was 0 IU/mL at this point. The median age of the 15 ...