The purpose of this study was to determine the efficacy and safety of a standard unfractionated heparin (UFH) protocol in obese patients based on total body weight (TBW) or adjusted body weight (ABW) to reach two consecutive therapeutic anti-Xa levels. This was a retrospective observational ...
(anti-Xa) level in a cancer patient with heparin resistance.A proven heparin-resistant patient with venous thromboembolism (VTE) and lung cancer who required approximately 66 000 units of unfractionated heparin daily was successfully transitioned to an off-label high-dose enoxaparin (OLHDE) 1.5 mg...
The discovery and clinical application of heparin have signifi-cantly improved the outcomes in numerous aspects of serious medi- cal conditions. In this light, several heparin-based agents, such as unfractionated heparin (UFH) and low molecular weight heparin (LMWH), are included in World Health...
The Heparin Anti-Xa Therapeutic Range The current ACCP recommendations for monitoring unfractionated heparin therapy accommodate for the well-known problem of significant variability in aPTT reagent sensitivity. Unfortunately, the recommendations do not account for or discus... MA Smythe - 《Chest》 被引...
The rate of clearance of unfractionated heparin may be decreased in patients with renal or hepatic impairment. Patients with renal or hepatic impairment, following similar doses of heparin may have higher plasma levels of heparin compared with patients with normal renal and hepatic function [see Warn...
The half-life of LMWHs is two to four times that of unfractionated heparin; for this reason, typical clinical regimes involve administration of LMWHs once a day and heparin twice a day (Hirsh and Levine, 1992; Wu, 2001). As both dp12 and LMWHs are the result of polymeric heparin ...
tauD UDP-glucose-dehydrogenase TriS trisulfate UDP uridine 5’-diphosphate UDP-GlcA UDP-glucuronic acid UDP-GlcNAc UDP-N-acetylglucosamine UFH unfractionated heparin ULMWH ultra-low-molecular-weight heparin USP United states pharmacopeia WHO World health organization Xyl xylose XylT xylosyltransferase. ...
50 Owing to their lighter weight compared with unfractionated heparin, LMWHs exhibit antithrombin III–dependent coagulation factor inactivation but also significant anti–factor Xa activity. LMWH activity may be assessed using an anti–factor Xa assay, available in many hospital clinical laboratories.51...
unfractionated heparin (UFH), three low-molecular-weight heparins (LMWHs; enoxaparin, nadroparin, dalteparin), fondaparinux, and dekaparin (a chemoenzymatically synthesized homogeneous anticoagulant dodecasaccharide) as comparators (Fig.5B). Meanwhile, all heparin anticoagulant factor (Xa and IIa) ...
“Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin”.N Engl J Med.vol. 332. 1995 May 18. pp. 1330-5.(A comparison of the incidence of HIT in a randomized controlled trial of unfractionated heparin vs. ...