A sample with known quinine-induced platelet antibody (QIPA), known to react with GP IIb/IIIa, was tested as a control Results: Reactivity of the QIPA was abolished on pretreatment of platelets in SPRCA assays with tirofiban, suggesting blocking of IIb/IIIa binding sites in the assay system....
IngvildBirschmann, JanGummert, UweSchirmer, CorneliusKnabbe, Ulrich J.Sachs, AndreasKoster. (2014) Non-transient “self-sustaining” heparin-induced thrombocytopenia: 4-year persistence of a platelet-activating PF4/heparin–antibody status without heparin exposure. Platelets , 1-2 /...
Results show heparin induced thrombocytopenia antibody screening after surgery is not warranted. Background Heparin-induced thrombocytopenia (HIT) is a prothrombotic response to heparin therapy with platelet-activating, anti-platelet factor 4 (PF4)/heparin antibodies leading to thrombocytopenia associated with...
Heparin-Induced Thrombocytopenia: Bovine Versus Porcine Heparin in Cardiopulmonary Bypass Surgery An abstract is unavailable. Konkle,A B.,Bauer,... - 《Annals of Thoracic Surgery》 被引量: 39发表: 2001年 Heparin-enhanced ADP-induced platelet aggregation in patients undergoing cardiopulmonary bypass surg...
Heparin-induced thrombocytopenia is an immune-mediated response that has been associated with bleeding and thromboembolic complications. We test all cardiac surgery patients who experience thrombocytopenia, resistance to heparin, or have complications of increased bleeding or thrombosis with platelet aggregation...
Reduced induction of anti-PF4/heparin antibody in RA patients after total knee arthroplastyHeparin-induced thrombocytopeniaPlatelet factor 4Rheumatoid arthritisOsteoarthritisTotal knee arthroplastyAnti-PF4/heparin antibodiesHeparin-induced thrombocytopenia is caused by antibodies (Abs) specific to platelet factor ...
Heparin-induced thrombocytopenia (HIT) is among the most serious potential complications of heparin therapy. Two forms are recognized: a nonimmunologic type I HIT, which causes a slight reduction in platelet counts with no clinical symptoms, and a less common immunologic type II HIT, which may be...
Rapid determination of anti-heparin/platelet factor 4 antibody titers in the diagnosis of heparin-induced thrombocytopenia Heparin-induced thrombocytopenia is mediated by antibodies directed against the heparin–platelet factor 4 (heparin/PF4) complex. Our aim was to investigat... L Alberio,S Kimmerle...
Summary. Introduction: Platelet-activating antiplatelet factor 4/heparin (anti-PF4/heparin) antibodies are the major cause of heparin-induced thrombocytope... A Greinacher,D Juhl,U Strobel,... - 《Journal of Thrombosis & Haemostasis》 被引量: 327发表: 2010年 Heparin-induced immune thrombocytopeni...
This article reviews type 11 heparin-induced thrombocytopenia, which is mediated by an antibody that in most cases has specificity for a complex between heparin and platelet factor 4, a secreted platelet cc-granule protein. The antibody-heparin-platelet factor 4 complex can activate platelets and ...