Using the 4T clinical score for HIT and the presence of heparin-associated Ab assayed by enzyme-linked immunosorbent assay and heparin-induced platelet aggregation, we define the phenotype of three groups of patients: 51 H/PF4/Ab patients with antibodies and without thrombocytopenia; 50 patients ...
Generation of platelet-derived microparticles and procoagulant activity by heparin-induced thrombocytopenia IgG/serum and other IgG platelet agonists: a co... Heparin-induced thrombocytopenia (HIT) is a relatively common, immunoglobulin-mediated adverse drug reaction associated with in vivo thrombin generatio...
Heparin-induced thrombocytopenia (HIT) is an important complication of heparin therapy. Although there is general agreement that platelet activation in vit... JG Kelton,JW Smith,TE Warkentin,... - 《Blood》 被引量: 741发表: 1994年 Prospective evaluation of PF4/heparin immunoassays for the diagnos...
5.3 Heparin-Induced Thrombocytopenia (HIT) and Heparin-Induced Thrombocytopenia and Thrombosis (HITT) HIT is a serious immune-mediated reaction resulting from irreversible aggregation of platelets. HIT occurs in patients treated with heparin and is due to the development of antibodies to a platelet Fact...
Heparin and insulin in the treatment of hypertriglyceridemia-induced severe acute pancreatitis. Dig Dis Sci. 2006;51(5):931–3. https://doi.org/10.1007/s10620-005-9006-z. Article PubMed Google Scholar Xiao AY, Tan MLY, Wu LM, et al. Global incidence and mortality of pancreatic diseases...
Effect of heparin bonding on catheter-induced fibrin formation and platelet activation. Pathologic and experimental evidence indicates that platelet activation and fibrin formation contribute to the pathogenesis of angina pectoris, coronary vasospasm and myocardial infarction. Detection of localized intravascular...
Besides its anticoagulant action, heparin also has unfavorableside effects, such as hemorrhagic complications and heparin-induced thrombocytopenia [69]. This together with the low incidence of the activepentasaccharideunit per heparin molecule and the inability of heparin to inhibit enzymatically active and...
Platelet factor 4Rheumatoid arthritisOsteoarthritisTotal knee arthroplastyAnti-PF4/heparin antibodiesHeparin-induced thrombocytopenia is caused by antibodies (Abs) specific to platelet factor 4 (PF4)/heparin complexes. In this study, we evaluated the rates of seroconversion of anti-PF4/heparin Ab between ...
HIT heparin-induced thrombocytopenia VTE venous thromboembolism PAOD peripheral arterial occlusive disease LMWH low-molecular-weight heparin UFH unfractionated heparin ULMWH ultralow-molecular-weight heparin AT antithrombin PF4 platelet factor 4 HC Ⅱ heparin cofactor Ⅱ PL phospholipid GAG glycosaminoglycan EGF...
Cardiovascular surgery for patients with a history of heparin-induced thrombocytopenia (HIT) with thrombosis requires careful perioperative anticoagulation therapy. When cardiovascular surgery is required for patients having ‘remote’ HIT, such as those