Dietary analyses have linked high fats and heme-iron intake to colon cancer and ovarian cancers, likely due to the generation of lipid peroxyl radicals that have DNA damag- ing capacities (Sawa et al. 1998; Yamaguchi et al. 2008). Transgenic mice fed a high iron diet were also shown to...
Red meat and processed meat intake is associated with a risk of colorectal cancer, a major cause of death in affluent countries. Epidemiological and experimental evidence supports the hypothesis that heme iron present in meat promotes colorectal cancer. This meta-analysis of prospective cohort studies...
We examined associations among colon cancer incidence and dietary intake of heme iron, a possible prooxidant, zinc, a possible antioxidant, and alcohol, a disruptor of iron homeostasis. During 15 years of follow-up, 34 708 postmenopausal women, aged 55-69 years at baseline who completed a food...
Red and processed meat consumption may play a role in lung cancer pathogenesis because of these meats' fat and carcinogen content. We prospectively investigated whether meat type, cooking method, doneness level, and intake of specific meat mutagens and heme iron are associated with lung carcinoma....
Iron can cause oxidative stress and DNA damage, and heme iron can catalyze endogenous formation of N-nitroso compounds, which are potent carcinogens. Dietary iron promotes esophageal cancer incidence in animal studies and has been identified as a growth factor for Helicobacter pylori, an established ...
metal,metallic element- any of several chemical elements that are usually shiny solids that conduct heat or electricity and can be formed into sheets etc. gadolinite,ytterbite- a mineral that is a source of rare earths; consists of silicates of iron and beryllium and cerium and yttrium and ...
Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats Thus, the differences in biomarkers were attributed to the formation of lipid oxidation compounds in food or during digestion, their intestinal absorption, ... ...
The meaning of HEME is the deep red iron-containing prosthetic group C34H32N4O4Fe of hemoglobin and myoglobin.
An enzyme that cleaves the ring structure of heme, releasing biliverdin, carbon monoxide, and iron. It is present in humans in two active forms: HO-1 and HO-2. Medical Dictionary, © 2009 Farlex and PartnersWant to thank TFD for its existence? Tell a friend about us, add a link ...
Cancer cell-specific mitochondrial reactive oxygen species promote non-heme iron uptake and enhance the proliferation of gastric epithelial cancer cell In the human body, iron may be present as heme or non-heme iron. The mechanisms governing the cellular transport of these forms have not been clear...