These findings reveal the principle role of iron as a regulator of gene expression in erythroblast maturation and suggest that the iron-heme-Bach1 axis is important for a proper adaptation of erythroblast to iron deficiency to avoid toxic aggregates of non-heme globin. 展开 ...
Whereas a low heme synthesis is responsible for porphyria1, heme intracellular accumulation is likely to be also deleterious through induction of intracellular oxidative stress as encountered in some ischemic and toxic conditions2,3. Of notice, circulating heme (free or bound to hemopexin) may also ...
Carbon monoxide(chemical formula CO) is a colorless, odorless, flammable and highly toxic gas. It is a major product of the incomplete combustion of carbon and carbon-containing compounds. Oxygenis a nonmetallic element constituting 21 percent of the atmosphere by volume. Oxygen is also found in ...
In addition, heme toxicity was inhibited by a 3 h preincubation of cells with either heme, apo-hemopexin, or heme-hemopexin 24 h prior to the toxicity assay. It is concluded, first, that toxic effects of iron and heme can be prevented by apo-transferrin or apo-hemopexin and, second, ...
Hemopexin and alpha-1-microglobulin are also involved in the protective system against toxic acellular Hb [10], [11]. Cell-free Hb may thus insert a substantial burden to our body at a range of conditions and the use of Hb protective and degradative proteins have been proposed to soon also...
Non-heme iron is relatively easy to come by in a vegan diet. And several studies have found that in general vegans are not more anemic than meat eaters. In fact, plant based diets tend to be higher in iron than other diets. In the US, about 10 million people (not vegans specifically...
Just as deficiency can cause problems, so can too much iron or hemochromatosis. It is a genetic condition that causes increased absorption of the mineral in the body. Toxic levels build up and can damage organs, especially the liver and kidney. Most cases of hemochromatosis are inherited, but...
Carbon monoxide(chemical formula CO) is a colorless, odorless, flammable and highly toxic gas. It is a major product of the incomplete combustion of carbon and carbon-containing compounds. Oxygenis a nonmetallic element constituting 21 percent of the atmosphere by volume. Oxygen is also found in...
Nitroxyl oxidizes oxygenated ferrous hemoglobin to methemoglobin and can convert the methemoglobin to a more stable, less toxic species, iron-nitrosyl hemoglobin. These results support the notion that Angeli's salt or a similar compound could be used to effectively treat conditions associated with ...
Hemoglobin constitutes 90% of the total protein in red blood cells, and its degradation also results in the release of large amounts of the iron-containing prosthetic group heme (13), which is very toxic when free in biological systems because it can enter membranes and damage cells (14). ...