While knowledge of HBPs in arthropods is accumulating, the data on HBPs of helminth parasites is scant. Annotated screening of genomic datasets ofS. mansoni[69] reveal a putative heme-binding protein, which shares a conserved tertiary fold structure with members of the SOUL/HBP superfamily [70]...
SOUL and p22HBP are part of an evolutionarily conserved heme-binding protein family. The SOUL protein is expressed in retina and pineal gland in the domestic chicken and solely in the retina in the murine form [5]. Murine SOUL (mSOUL) has 27% sequence identity to murine p22HBP (mHBP) an...
The amount of active Nrf2 in the nuclear extracts was determined by subjecting 20 µg of protein sample to assay with a TransAM Nrf2 DNA Binding ELISA Kit (Active Motif). The assay was performed according to the manufacturer's protocol. As a positive control, BAECs were incubated with a...
Hybrid-based drugs linked through a transition metal constitute an emerging concept for Plasmodium intervention. To advance the drug design concept and enhance the therapeutic potential of this class of drugs, we developed a novel hybrid composed of quin