if necessary, given an intravenous infusion of normalsaline. A transienthypotensiveresponse is not acontraindicationto further treatment, which usually can be continued without difficulty once the blood pressure has stabilized.
In hemodynamic studies, amlodipine has not been associated with a negative inotropic effect when administered in the therapeutic dose range to intact animals and man, even when coadministered with beta-blockers to man. Similar findings, however, have been observed in normal or well-compensated ...
The pharmacokinetics of hydrochlorothiazide is dose proportional in the range of 12.5 to 75 mg. Distribution Olmesartan:The volume of distribution of olmesartan is approximately 17 L. Olmesartan is highly bound to plasma proteins (99%) and does not penetratered blood cells. The protein binding is ...
NK cells are one of the first lymphocyte populations to recover after HCT, reaching normal population numbers months before recovery of memory and effector CD8+ lymphocytes, which would agree with the timing of relapse protection observed in our cohort.23 Moreover, graft-versus-leukemia effects of...
In patients with impaired hepatic function, amlodipine should be initiated at the lower end of the dosing range and caution should be used, both on initial treatment and when increasing the dose. Use of Sanoral HCT is contraindicated in patients with severe hepatic impairment, cholestasis or bilia...
(2.5 μg/mL) decreased the survival rate of cells time-dependently (Fig. 1B). However, COP treatment induced relatively low cytotoxicity in FHC compared to that in HCT-116 cells (Fig. 1C,D). Based on the results, we chose the optimum concentration range (1–10 μg/mL) and ...
We also measured the effect of COP on normal cells (FHC) using flow cytometry. The result shows that after treated with 100 μg/mL of COP, the percentage raised obviously, which is twenty times higher than the one of HCT-116 cells. Therefore, these results suggest that COP is a ...
As part of our investigation into the genetic basis of tumor cell radioresponse, we have isolated several clones with a wide range of responses to X-radiation (XR) from an unirradiated human colorectal tumor cell line, HCT116. Using human cDNA microarrays, we recently identified a novel gene...
If hypotension occurs, the patient should be placed in thesupineposition and, if necessary, given an intravenous infusion of normalsaline. A transienthypotensiveresponse is not acontraindicationto further treatment, which usually can be continued without difficulty once the blood pressure has stabilized...
0=normal; 0.5=focal and rare; 1=focal and mild; 2=diffuse and mild; 3=diffuse and moderate; 4=diffuse and severe, adapted from (Hill, G. R. et al. Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood 90, 3204...