As with other calcium channel blockers, hemodynamic measurements of cardiac function at rest and during exercise (or pacing) in patients with normalventricularfunction treated with amlodipine have generally demonstrated a small increase incardiac indexwithout significant influence on dP/dt or on left ven...
In hemodynamic studies, amlodipine has not been associated with a negative inotropic effect when administered in the therapeutic dose range to intact animals and man, even when coadministered with beta-blockers to man. Similar findings, however, have been observed in normal or well-compensated ...
NK cells are one of the first lymphocyte populations to recover after HCT, reaching normal population numbers months before recovery of memory and effector CD8+ lymphocytes, which would agree with the timing of relapse protection observed in our cohort.23 Moreover, graft-versus-leukemia effects of...
In a small study, breast milk was collected every 2 to 3 hours over one dosage interval, in three mothers (at least 3 monthspostpartum) who took metoprolol of unspecified amount. The average amount of metoprolol present in breast milk was 71.5 mcg/day (range 17.0 to 158.7). The average ...
In patients with impaired hepatic function, amlodipine should be initiated at the lower end of the dosing range and caution should be used, both on initial treatment and when increasing the dose. Use of Sanoral HCT is contraindicated in patients with severe hepatic impairment, cholestasis or bilia...
The protein binding is constant at candesartan plasma concentrations well above the range achieved with recommended doses. In rats, it has been demonstrated that candesartan crosses the blood-brain barrier poorly, if at all. It has also been demonstrated in rats that candesartan passes across the ...
In addition, human colorectal epithelial cells (FHC) was also used to determine the cytotoxic effect of COP in normal cells. vs As shown in 282.2 μg/mL Fig. 1A, in HCT-116 cells, COP exhibited cell cytotoxicity at a in FHC). Besides, COP (2.5 μg/mL) decreased ...
Using murine models of fully- and partially-MHC-mismatched HCT, the inventors showed that GM-CSF (Csf-2), a cytokine with an emerging role across a range of inflammatory disorders, is abundantly produced by donor T cells early after transfer. When donor T cells lacked GM-CSF, GvHD was sig...
(2.5 μg/mL) decreased the survival rate of cells time-dependently (Fig. 1B). However, COP treatment induced relatively low cytotoxicity in FHC compared to that in HCT-116 cells (Fig. 1C,D). Based on the results, we chose the optimum concentration range (1–10 μg/mL) and ...
Abutilon indicum-assisted AgNPs showed dose-dependent anti-proliferative effects against COLO 205 (human colon cancer) and MDCK (normal) cells [37]. Figure 2. Cell viability and proliferation assessment of AgNPs in HCT116 and HT-29 cells. (A,B) Viability of HCT116 and HT-29 cells was ...