pKaand ID50 values are means ± S.E. from the fit curves. ND, not determined. Empty Cell[35S]SO4 influx in pH 6.4 citrateApparent pK a for SO4 uptake1-aID50 for DIDS1-bExtrapolated [DIDS] for maximal inhibition1-b mmol/1013 cells × h pH units μm μm L family II:5 RTA...
CHES pKa of 9.50 If I have 1 liter of a 1M solution of HCl, how many grams of NaOH must I add to neutralize the solution and adjust the pH to 7? Fill in the blank. Chemical buffers r...
This channel was stimulated by cAMP (cell-attached configuration) and by PKA + ATP + cAMP (inside-out configuration). The channel was inhibited by NPPB (10−5 M), but not by other anionic inhibitors. Measurements of the pdcm value suggested that in isolated cells, as in whole tissue, ...
The pH-sensitive residues are mainly located in the GluN2 N-terminal domain, determined by mutagenesis study [40] and pKa prediction of titratable residues based on the high-pH model of the GluN1-GluN2A structure [41]. What percentage of the Na+ current relative to cotransport would be ...