2. 非编码 RNA(noncoding RNAs,ncRNAs):ncRNAs的主要成分是 microRNA(25～30 bp)和长非编码 RNA(>200 bp),它们是不翻译成蛋白质的 RNA 分子,是参与染色质改变、DNA 转录和染色体环化的重要调控元件。它们在血液中的稳定性,以及...
Circular RNAs (circRNAs), a specific series of noncoding RNAs with covalently closed, single-stranded structures and lacking a 5’ cap and 3’ poly(A) tail4, have long been considered “waste” produced during RNA splicing. In recent years, a large number of circRNAs in mammalian cells have...
Currently, although surgical resection is a first-line treatment for HCC, most patients with HCC are not suitable for surgical resection or liver transplantation because they are in an advanced stage of diagnosis with regional diffusion and metastasis. Moreover, postoperative recurrence and metastasis ...
Radiotherapy has emerged as a promising locoregional treatment option for HCC16,17. A randomized control trial (RCT) showed that, for patients with a single and small HBV-related HCC at high risks of microvascular invasion, neoadjuvant intensity-modulated radiotherapy (IMRT) provided a promising resp...
for determining payment level for Medicare Advantage Plans. The difference in diagnosis of patients and outcome of their health makes for the risk- adjusted payment. Patients suffering multiple chronic conditions are prone to greater risk scores. For physicians practice accurate HCC coding becomes an ...
A pathological diagnosis of HCC was made in all patients, and all tested positive for hepatitis B virus (HBV). The mean age of these patients was 54.67 years. The clinical stage was I or II, and the case grading was around medium (Supplementary Table 1). Genomic DNA extraction and WGBS...
(B) RNA-seq data from human NASH patients and normal individuals (left) and MUP-uPA mice fed either HFD or normal chow (right). All terms are enriched with p < 0.05; the color coding represents the p value for enrichments calculated for the MUP-uPA + HFD mice, the darker red the ...
1 The onset of HCC is insidious and most patients are identified at advanced stages, which lead to a poor prognosis.2 Early diagnosis and treatment is the primary strategy to improve the prognosis of HCC patients, and identification of non-invasive biomarkers is essential to the early detection...
The role of long noncoding RNA (lncRNAs) had been demonstrated in different types of cancer, including hepatocellular carcinoma. This study was intended to investigate the role of lncRNA small nucleolar RNA host gene 5 (SNHG5) in HCC proliferation and th
Transcription factor ERG (erythroblast transformation-specific (ETS)-related gene) is essential in endothelial differentiation and angiogenesis, in which microRNA (miR)-200b-3p targeting site is expected by miRNA target prediction database. miR-200b is k